ID   A0A1S3ISW1_LINUN        Unreviewed;       677 AA.
AC   A0A1S3ISW1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE            EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE   AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN   Name=LOC106166909 {ECO:0000313|RefSeq:XP_013401026.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013401026.1};
RN   [1] {ECO:0000313|RefSeq:XP_013401026.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013401026.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC       {ECO:0000256|ARBA:ARBA00005637}.
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DR   RefSeq; XP_013401026.1; XM_013545572.2.
DR   AlphaFoldDB; A0A1S3ISW1; -.
DR   STRING; 7574.A0A1S3ISW1; -.
DR   EnsemblMetazoa; XM_013545572.2; XP_013401026.1; LOC106166909.
DR   GeneID; 106166909; -.
DR   KEGG; lak:106166909; -.
DR   InParanoid; A0A1S3ISW1; -.
DR   OrthoDB; 5487508at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR049162; GH59_C.
DR   InterPro; IPR049161; GH59_cat.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR035394; Glyco_hydro_59_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR   PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   Pfam; PF21708; Glyco_hydro_59_C; 1.
DR   Pfam; PF17387; Glyco_hydro_59M; 1.
DR   PRINTS; PR00850; GLHYDRLASE59.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..677
FT                   /note="galactosylceramidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010222773"
FT   DOMAIN          42..335
FT                   /note="Glycosyl hydrolase family 59 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02057"
FT   DOMAIN          348..461
FT                   /note="Glycosyl hydrolase family 59 central"
FT                   /evidence="ECO:0000259|Pfam:PF17387"
FT   DOMAIN          498..676
FT                   /note="Glycosyl hydrolase family 59 C-terminal lectin"
FT                   /evidence="ECO:0000259|Pfam:PF21708"
FT   ACT_SITE        185
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601286-50"
FT   ACT_SITE        260
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601286-50"
SQ   SEQUENCE   677 AA;  74660 MW;  6A04F59A5F9A2F86 CRC64;
     MEMGHAYNFF VLLAFPGLIL SRAQCALQKV NVDDSYGVGR NFDGIGAISG GGATSKLLVN
     YPEAQRNQVL DFLFKPNFGA SLQILKVEIG GDSQSTDGVE SSHMHTEVDV SFQRGYEWWM
     MKEAKKRNPN IKLYGLPWVF PGWLGNGTFN PYAMREKLVY YITSWIKGAA KVHNLQIDYI
     GIWNERSYDI DYIKMLRKSL DNQGFSHTQI VAADGGWGIA SDVLKDPDLA NAVSILGAHY
     PGSMATADAQ KTGKKLWASE EYSAFNNLAG GGCWARVLSE GYVNGNLTSA IAWNLISSYS
     AALPYSGSGL MTANQPWSGY YVVNTPIWMS AHYTQFTEIG WSYLDHGHGS GHLDSNGSYI
     ALTSPDRSQL TIVIENMDPH DAPCFYPMPK YTVAPQTVTF TLKGSFSKIQ ELDVWFTHFN
     FTQGGHSDIF IYQGPMKVVN GSFSLTVMPN VVITLTTVKS GRKGQYPAPP PPAPFPLPYK
     DTFQDYAEFS EPYNLAPQAG SFEIRSSSEP GITKVLRQVV PQPPIDTCLP KRMPRPIAVI
     GNHSWADVRV EITCRVPASN GSSGVFIASR VSSGGCSAMY SNGLYFWLLL GERKFLLSSD
     YAQKVVYANG TLPNSIDFNT WTSMSLFAQG KKVRGMLNSK DVFNLELKTV VSAYGFVAIG
     TNDFGMADFI NMFIDKT
//