ID   A0A1S3ISW2_LINUN        Unreviewed;       872 AA.
AC   A0A1S3ISW2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Uncharacterized protein LOC106167140 {ECO:0000313|RefSeq:XP_013401300.1};
GN   Name=LOC106167140 {ECO:0000313|RefSeq:XP_013401300.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013401300.1};
RN   [1] {ECO:0000313|RefSeq:XP_013401300.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013401300.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   RefSeq; XP_013401300.1; XM_013545846.1.
DR   AlphaFoldDB; A0A1S3ISW2; -.
DR   STRING; 7574.A0A1S3ISW2; -.
DR   EnsemblMetazoa; XM_013545846.1; XP_013401300.1; LOC106167140.
DR   GeneID; 106167140; -.
DR   KEGG; lak:106167140; -.
DR   InParanoid; A0A1S3ISW2; -.
DR   OrthoDB; 5405271at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT   DOMAIN          626..750
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          770..858
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
FT   REGION          40..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  99831 MW;  BB0BA5B9E75577CD CRC64;
     MAIGIQKPKT FGDPVEMVQT PPAESLTDVK GGIFNGMVTK RASSTGDSRS YTSPDRAAAA
     NPDDGGSHAS PVRTVERDYI KNIDPDLLDK IEKLARGQPV EPEKQVTIWD FGGQDVYYTT
     HQTFLSEHII YLLVFRLDVD LDRKIPVYRG QKTVKEFIMF WLNSIHMHTV ERLREEDRDV
     IPYVLIIGTH KDRLGSQVDV KDIFGKLSKC LDDKQVLKDH VYQYFAINNL AEDDAEFDKI
     KRVIEKLCGY SSDSKATVQK FSVGWIQLEM DLAKKSEEIP IITVEELCKM AQRVGLSDGE
     LQDSFIPYHH QQGDILHFKV DGLENIVIID PLWLADVFSA IMTPTSSHPG CSYGDILKDE
     LKRGVLKEEV FDEYLKEIKM TENKTEIIQL MLHFDLMLEI SQSVENPIPG SGKRRFVVPS
     MLVSNNNANN ALSESDPQKY LLIAFPHIPF PTGLFHRLII RLLRKYKAQR YENNIPVVGF
     DRASFRLEDK QSVLHLVVED KVIKLLITNA TGNPPKPHMY ANTRKTVEDE LSTLRNTYCP
     RMHFVYCIRI KDDGPNIQIQ AQDVQTREVI CACLETSEVS IDLRPYRVWF SHEEKEQRRP
     QSMEEDDLFR DKAFDDKQVY RNYTEWRGKA VIINNISFDN RYYPDRDGTE VDVERLEILF
     KQLHYLVSKH DNLSAGSINQ LAEREARSDH SAYSSFIMVV LSHGSENTVI GTDGYHIGYD
     QIMAHFEASR CPTLSGKPKM FFISACQSSP VENAAVLDTK PKQATAKQQE TPQTPEKADM
     ILVLATTRGD RSWRTPANGT WFIQNLVTEL SERARETHLL DILTQVNQSV SQMTTQEGCR
     QVSTIAMCTL RKHVYFWPGY YCENGEIKQY PQ
//