ID A0A1S3ITU4_LINUN Unreviewed; 746 AA.
AC A0A1S3ITU4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like {ECO:0000313|RefSeq:XP_013401503.1};
GN Name=LOC106167305 {ECO:0000313|RefSeq:XP_013401503.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013401503.1};
RN [1] {ECO:0000313|RefSeq:XP_013401503.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013401503.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013401503.1; XM_013546049.1.
DR AlphaFoldDB; A0A1S3ITU4; -.
DR STRING; 7574.A0A1S3ITU4; -.
DR EnsemblMetazoa; XM_013546049.1; XP_013401503.1; LOC106167305.
DR GeneID; 106167305; -.
DR KEGG; lak:106167305; -.
DR InParanoid; A0A1S3ITU4; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 36..133
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 154..276
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 680..742
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 435..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_013401503.1"
SQ SEQUENCE 746 AA; 82114 MW; 6D5CEB22744372B0 CRC64;
LTKLNSHRFS VLLAPVLGST HPTHALPQIL GNKTLGTEKK GHLLKKSEGR MRKVWQRRRV
AIQSGIMSVS HSDESKDPVR LNLLTCQAKL VLDDPTKKCF DLISSSNNRT YHFQAEDTAD
MEEWIAVLNN AKEEILMKAF GDSTGSGHLR ELTRSIIDQI RRLPGNAYCC DCGAEDPEWL
STNLGILICI DCCGIHRDLG VHISRTQSLV IDEIGTSQLL LARVVSNRSF NDIMEATLDT
SYKPTSTSTM EERKEFIRAK YERHRYAIKT CLTMEDLKLD LKQAVLSADI YGLLQVFAEG
QDLMAVLPDT EDEETALHLA VKQTDGMSLH IADFVIQNTN NRNLDMATRD GYTALHYCAQ
ANRTEEMKLL LRACPALASV ETKDGRTAMD IAREENNEHC IDLLKHALEG KTKLFENVNI
DWDLVSSDEN TLDTVDYSDD ELEDRGTPDK KNRSRPPSLV MTKDSIIPIP ARERRSSLGD
GLKVNLNNLP PPPPPQSSKP KGLTFSSTAP LASVSVGLAG KKKAPAPLPP GVGSGHTRMV
SDPSGINLDQ VNRARVPSDP SMPPPLPMKN KDKIQAPPGG KLVLPPPLQF RNQTGAVSSN
SGKKSRTSSA SSDKPVPAPR RSTIGGAPVF SQPEAVKAAS SMERLSNGRS SESLDSTDSA
AGGGLQPHPT PRTKKKMSLR RQRKCRALYD CDADNDDELS FKEGEIIILL REEDEDWWEG
EVDGEPHRKG LFPASFVERV VEDSGG
//
