ID A0A1S3IXQ8_LINUN Unreviewed; 371 AA.
AC A0A1S3IXQ8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN Name=LOC106167970 {ECO:0000313|RefSeq:XP_013402334.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013402334.1};
RN [1] {ECO:0000313|RefSeq:XP_013402334.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013402334.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR RefSeq; XP_013402334.1; XM_013546880.1.
DR AlphaFoldDB; A0A1S3IXQ8; -.
DR STRING; 7574.A0A1S3IXQ8; -.
DR EnsemblMetazoa; g2311.t1; g2311.t1; g2311.
DR EnsemblMetazoa; XM_013546880.1; XP_013402334.1; LOC106167970.
DR GeneID; 106167970; -.
DR KEGG; lak:106167970; -.
DR InParanoid; A0A1S3IXQ8; -.
DR OMA; YDVPHER; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd01011; nicotinamidase; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR11080:SF2; LD05707P; 1.
DR PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 32..67
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 74..109
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 371 AA; 42291 MW; 46FB5FAF7472081D CRC64;
MATHNSSQPA DSRVNDFPQN FFDKYRKSGA TRDGGKMQEC FRTFDTDRDG YLNTLEFDGL
LSQLFSKRGK PYLLTDSQRT ELFNLVDSNK DGKIDSEEFK NCWHKWISQI LDPVTALIIV
DVQNDFISGS LAIQEGELIV SPINNILDTY KFDLVVYTLD WHPHDHISFV ENVKKREIDP
ASKVKAEHAK VQDEVIFRIP GYEEGRIQTV WPRHCVQNTE GAKLHKDLKL LNNALYINKG
TDPDIDSYSA FWDNGKLRQT QLEAELRKRK VTDVYVCGLA IDICVRFTSL DSIAHGFRTI
LIDNACKGVD QQSVEPSREQ IRKSGGLCID ICEMGDIYSL VDRRPEIGLH AARTALGGKK
CDEIERRVIT Q
//