ID A0A1S3IXZ9_LINUN Unreviewed; 515 AA.
AC A0A1S3IXZ9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ras-GEF domain-containing family member 1B isoform X3 {ECO:0000313|RefSeq:XP_013402861.1};
GN Name=LOC106168352 {ECO:0000313|RefSeq:XP_013402861.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013402861.1};
RN [1] {ECO:0000313|RefSeq:XP_013402861.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013402861.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013402861.1; XM_013547407.2.
DR AlphaFoldDB; A0A1S3IXZ9; -.
DR EnsemblMetazoa; XM_013547407.2; XP_013402861.1; LOC106168352.
DR GeneID; 106168352; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF356; FI05912P-RELATED; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 86..217
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 252..497
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 59621 MW; F21FA570C188F2D7 CRC64;
MWKRRSKSFN LGTCPSSRSQ PAIGLKQTPK SRPSIFGTLA KDKSPAHQDS RRSIGPQMMS
LCHMFRSSGD GYDGLTVDEN DALIFQDGNL LAGSLDALIR HLVPTAEYYP DRTYTFAFLL
SSRLYARPHE LLKEVCKLCK SQQHLEDGEK VNKEKLGKFG PNIIQLLGEW TEMLPYDFRD
ERMMKQLKEI TQKIVTIYPE LRKEVGMIMH DLITKLSSLQ KYEEALQKIN AEATQRLKHI
VPTTDIVQMC PSPLDLAQQL THIELERLTN IGPEEFVQAF AKENELQTSY DDMKKTSNLE
AYVQWFNRLS YLVATEICMH LKKKHRVRTI EYFVDVAKEC FNIGNFNSLM AIIAGMNMSP
VARLKKTWSK VNTQKFEILE HQMDPSNNFS SYRSTLKAAL WRCEGAVEER EKIVIPFFSL
LVKDIYFLNE GCANRLPNGH INFEKFWQLA KQITEFITWK QVECPFERQS HVLNYVLTNP
VFSENSLSLA SFECEPPENS YEKERYKNVK SEMEL
//
