ID A0A1S3IYS1_LINUN Unreviewed; 689 AA.
AC A0A1S3IYS1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=LOC106168562 {ECO:0000313|RefSeq:XP_013403130.1,
GN ECO:0000313|RefSeq:XP_013403131.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013403131.1};
RN [1] {ECO:0000313|RefSeq:XP_013403130.1, ECO:0000313|RefSeq:XP_013403131.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013403130.1,
RC ECO:0000313|RefSeq:XP_013403131.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_013403130.1; XM_013547676.1.
DR RefSeq; XP_013403131.1; XM_013547677.1.
DR EnsemblMetazoa; g12571.t1; g12571.t1; g12571.
DR EnsemblMetazoa; XM_013547676.1; XP_013403130.1; LOC106168562.
DR EnsemblMetazoa; XM_013547677.1; XP_013403131.1; LOC106168562.
DR GeneID; 106168562; -.
DR KEGG; lak:106168562; -.
DR OMA; KMIVCCH; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd17403; MFS_SLCO4_OATP4; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF100; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 213..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 249..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 296..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 396..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 558..582
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 645..668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 89..669
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 475..530
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 74540 MW; DBFAE531C402165A CRC64;
MAEVHNSTQN AEASYGPSVS NGHGDAHLKP TDQPQEQADQ TVQNLPTVCK DCGVLDTLEC
GCKENPEDQC GWGKLEPDCV QKCHNAKCLL FCLCFMVTIQ GMVVNGFVSS SITTLEKRFN
LSSTQAGVID AGYDIATVLV LVFVSYYGGR GHKGKWIGVG TILLGFGSVI FIIPQFTTGL
YAAQEREDVC VLDSNNNQTD FCQSPDAHLS DYFYVFFLGQ MVQGFGCSPM FTLAFVYLDE
NVSTKESPLY TGIYYGISVI GPALGYVLGG VLLNLYGDIG QVDISSVTIS PDSPSWYGAW
WLGFLGTAVM SWIIAFPLLG FAAELPGALK IKEEKKKSNS TAFDSNLMDL GAAMKRLFQN
ATFVCIVICD AVEGFLVGGF IAFAPKYLEN QFSMSASQAS ILTGVVVVPA GGGAAMLSGF
LLRKLSFSCA NIIKFGFIVL LISFFCCFGL FVRCDNMPFA GVGALQPGGY HESASNMTLE
CNIHCGCLQD FYNPVCGDNG VTYFSPCYAG CLTKNILESD NYYNNCSCVQ FHSSGLMNNS
MTKAKEGPCS TSCTLMPLYQ VVLLFLITFT FLASTPTVQA ILRSVQECDK SLATGVGWVA
VRLLGLIPGP IVFGAILDSA CIVWGEECGQ RTSCHQYDNE RMSYYFVALS ASFKAVSSLL
MFLAWYLYKP VPGSACYAED ATGEEVCQL
//
