ID A0A1S3IZZ9_LINUN Unreviewed; 740 AA.
AC A0A1S3IZZ9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=PC3-like endoprotease variant B {ECO:0000313|RefSeq:XP_013403777.1};
GN Name=LOC106169035 {ECO:0000313|RefSeq:XP_013403777.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013403777.1};
RN [1] {ECO:0000313|RefSeq:XP_013403777.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_013403777.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR RefSeq; XP_013403777.1; XM_013548323.2.
DR AlphaFoldDB; A0A1S3IZZ9; -.
DR STRING; 7574.A0A1S3IZZ9; -.
DR EnsemblMetazoa; XM_013548323.2; XP_013403777.1; LOC106169035.
DR GeneID; 106169035; -.
DR KEGG; lak:106169035; -.
DR InParanoid; A0A1S3IZZ9; -.
DR OrthoDB; 2916537at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..740
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010360036"
FT DOMAIN 460..586
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 610..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 165
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 203
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 382
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT NON_TER 740
FT /evidence="ECO:0000313|RefSeq:XP_013403777.1"
SQ SEQUENCE 740 AA; 81180 MW; FE422672023AA2E7 CRC64;
MTTAAIVAIL WCLVTVTTSS GTLDESVQNI DGDTEDGYTN VWAVEIAGGE DVARRLALKH
GFEHIAKIYD DYYMFEHKDV PDFDRYSSEE KHGTLSSDPE VKWLKQQKVV KRSLFGQTPG
GTLGVHDDRW RDQEWYLNNT VLGMNIVEAW ERCRTGQGVN VAVVDDGIDY TNYDLARNFD
LFNSYDMQVD RKTPMPGIAS DSHGTSAAGI IGAEANDFCG VGIAFDANIA GIRIFGNKRI
TDALEARALT YNMETVDVYS CSWGMARTGF DLKAIGELSK GAMKKGATEG RGGKGSIYVF
ASGNGGTNDD SCAYDGFANS IYTIPVGGLT HRGRKLPTGE KCSAMMATAY SKSSMEPNRW
YDKIFTTGYG QWTCADDFGE SSAAAPMVAA VIALALEANP SLTSRDVMHL ITRSARSDFA
RYDPDSGWFV NGAGFHVSST FGFGLLDAAK MVDFAERWQN VPEQTKCSKQ MTGINGKLPG
TTTVDFRSCD IKFVEHVEVF VFVYFAGRGY VKMELESPVG TRSLMIPGRK NDLWSRYLEL
NVSSVQFWGE QGTGDWKVHI GSIYPDQNHT GTLFDLTVNI YGTKDGFPVK LSTTNNNTCN
QGVVSGFVPT PYPPSRARPT DVHRPTPAPS TTMAPTVTST RQAESTTKKT LFSCRCSFLD
TIQSYKFRFV SGSVGLEVSC PTDLTTTQYS TCTFISSPLK GWPPGNQACN CSSVDLNKDT
GTWLVTYPDV EFRLQVLCPV
//
