ID A0A1S3J2Q7_LINUN Unreviewed; 365 AA.
AC A0A1S3J2Q7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Homeobox protein Nkx-3.1 {ECO:0000313|RefSeq:XP_013404533.1};
GN Name=LOC106169586 {ECO:0000313|RefSeq:XP_013404533.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013404533.1};
RN [1] {ECO:0000313|RefSeq:XP_013404533.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013404533.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family.
CC {ECO:0000256|ARBA:ARBA00038425}.
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DR RefSeq; XP_013404533.1; XM_013549079.1.
DR AlphaFoldDB; A0A1S3J2Q7; -.
DR STRING; 7574.A0A1S3J2Q7; -.
DR EnsemblMetazoa; g2529.t1; g2529.t1; g2529.
DR EnsemblMetazoa; XM_013549079.1; XP_013404533.1; LOC106169586.
DR GeneID; 106169586; -.
DR KEGG; lak:106169586; -.
DR InParanoid; A0A1S3J2Q7; -.
DR OrthoDB; 5398360at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24338; HOMEOBOX PROTEIN MSX; 1.
DR PANTHER; PTHR24338:SF0; MUSCLE SEGMENTATION HOMEOBOX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 206..266
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 208..267
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 42..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40118 MW; 604B8B7FE10317A1 CRC64;
MMATTSAKYP RLAVAPSVSS FSIQGLHPAF FSVANSRSSK AYATEKLNPE SPVPSPTTEG
GENESSTLGG PQSSTNREHL EESRSPSPLI THKNPMVQSG HTLTLGQLFH STPTNTSGHS
LTKFSIEEIL GRKEGKCRGS DWKPTHENSR GMDNDSEEKS NVSGTLDKFT LDGDEQLSHF
SWLQCTRYKP PKLPRLKRKD GVKKRKLGRN PRVPFTQHQV KTLEEKFRRT HYLSSVDVAE
LSAALNLTET RVKIWFQNRR ARERRDRDQT NGNTVSPPPS VASQRSTNGS ASTSTNIINF
PWLGPIPPKP SAVAQFSHAI HFGTSAFSPV SFAGLPAPLA ATLTSPLAYP TNIHSSAVLP
WVLRE
//
