ID A0A1S3J4X6_LINUN Unreviewed; 1631 AA.
AC A0A1S3J4X6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Low-density lipoprotein receptor-related protein 4-like {ECO:0000313|RefSeq:XP_013405316.1};
GN Name=LOC106170118 {ECO:0000313|RefSeq:XP_013405316.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013405316.1};
RN [1] {ECO:0000313|RefSeq:XP_013405316.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013405316.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013405316.1; XM_013549862.2.
DR STRING; 7574.A0A1S3J4X6; -.
DR EnsemblMetazoa; XM_013549862.2; XP_013405316.1; LOC106170118.
DR GeneID; 106170118; -.
DR KEGG; lak:106170118; -.
DR InParanoid; A0A1S3J4X6; -.
DR OrthoDB; 3404277at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00058; Ldl_recept_b; 6.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00135; LY; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS51120; LDLRB; 10.
PE 4: Predicted;
KW Lipoprotein {ECO:0000313|RefSeq:XP_013405316.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_013405316.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1631
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010219092"
FT TRANSMEM 1501..1528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 84..127
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 172..215
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 306..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 443..485
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 486..529
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 642..684
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 685..728
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 729..771
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 822..859
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 909..952
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 953..995
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 996..1040
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1133..1170
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1233..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1587..1631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1587..1602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1631 AA; 179224 MW; 77C77CE8CB0F3BD2 CRC64;
MCSGVCHGLR LAVISLFCVS SVTSITHGQN LIWAQRSPSG VARIVGIPGD PADWVESKKA
STRYITAPNK DWHFVALAHD YRQKILYWSD RGNKKLQGLR LNGSTHAFTI FGGISSRVEG
LAVDWVAGNI YWVDAVYNWL VVAPATEQTG AYRVLFDDLD TPMGVAVHPH EGHLFWSDRG
AAPRIEKSTL SGENREILVN SGLVSPGAMV IDMSRDLLYW ADNAKDTLES VDLLGRHRKV
IQTAPGTDFY GLALYKDLIF VTEQSIKQLR IYGEKEQKNI LNFNLPAVPY GIIMYDDSVQ
PNGSVPCDVM DCQDLCVSTG RGGAKCMCTN GFVLDTDGRS CKADDGKFGA PQLIYSIGGA
ICRFQANLPD MSMTNISLDD QCFLKNRKNV VSLSCNVYEE AIYFAENVTR TISKVRLSHG
EAPQVIAGGL GHVEGLAVDW LGNNIYWTDS EMRHIAVSTL AGRYQHILIQ DDLEHPRAIA
VDAVRRKLYW SDIGSKPSIQ VANMDGGGRA TLIETSLGSP NDITVDMVSK SHVLCRRVPF
PADDGKFGAP QLIYSIGGAI CRFQANLPDM SMTNISLDDQ CFLKNRKNVV SLSCNVYEEA
IYFAENVTRT ISKVRLSHGE APQVIAGGLG HVEGLAVDWL GNNIYWTDSE MRHIAVSTLA
GRYQHILIQD DLEHPRAIAV DAVRRKLYWS DIGSKPSIQV ANMDGGGRAT LIETSLGSPN
DITVDMVSKR LYWTDSVLRR IESVDLRGRD RKTLVVTGDS EFRGLVTFKD YLLWTDQGTR
NGLHIAMKDT GQKVRGVVHP NTGTAYDILA YDYQHQPTVE GACDDENGGC DHLCLLNQEG
RSCACAIGYS LASDGKRCLS ETVKDDFLIF TDTYQKQIFQ MSLKDSEIRA VPLKGHENPI
AVDYDPKEGR VYWSDVLMQV IKRAYINGTG QEIIKVLPDA SVVDGVAVDP LSRLLYYTDT
GRNVIGVMSM DGRYSKILIN ESLDEPRSIA LDPMHGHMYW TDWGERPKLE RANMDGSSRL
SIINFDIGAW PNGLAVDTGA GQIYWADARF DKVMTSNLFG QEPRSLFEDS NAHYFGIAIA
GDYIYYSDWR KKSVMRISKY GSRSPTPVGP ALFNRLNDIH AYRKSEAMAG RNACSEYNGF
CSHLCLPVLG GKQCACPTGM SLKIDGFHCQ NGHSIFTYYT QHTTRSTTPL TTRRTTTPFE
VIRGSVGRWT TAGGVGDNRS QVGGAVDRFK LEKRGKTTAS VESSDGGSNE ELNINGRTPG
TRASTTRSST TTVSPSPTPP ATSLTTPFLS NQTTTYRTNK DFVATESTTF KPATTSPTPM
PIDSTEWTDI KTDRQTDRLT DRQTDRPPPW PSESSVRTEY TTAFSMRSTS TASSSIVPAY
VQSSSIITQS IASTTNSYTV TATATSVATG SSVSHVAQPV TRMSSTTSPP STRQTPRSTA
FQSRPVLNIS ETATLTAPPG DQFVTTQLTN YSTVPKPSIT TEQNTKNSSV TVSSSKERTD
LATIGIIIGA AAGGACVVIM AIVCVVVVCK QRSSRKPRTQ RSGHGLYIDQ TNFNTMETSF
SNGTRPPSSY DPIDPRLFST GFDNQTFSRP SSISTSEFTT YTDPAPPEDR HHHSHHPHHH
HQQGGFSTFK V
//
