ID A0A1S3J7W9_LINUN Unreviewed; 1919 AA.
AC A0A1S3J7W9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 isoform X5 {ECO:0000313|RefSeq:XP_013406408.1};
GN Name=LOC106170911 {ECO:0000313|RefSeq:XP_013406408.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013406408.1};
RN [1] {ECO:0000313|RefSeq:XP_013406408.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013406408.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_013406408.1; XM_013550954.1.
DR EnsemblMetazoa; XM_013550954.1; XP_013406408.1; LOC106170911.
DR GeneID; 106170911; -.
DR OrthoDB; 2917157at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20815; C1_p190RhoGEF-like; 1.
DR CDD; cd13329; PH_RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF21; CYSTS, ISOFORM C; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 488..536
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 718..909
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 19..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1595..1638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1544..1571
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 53..75
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..484
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1919 AA; 216394 MW; 9E7E6412036E0095 CRC64;
MEMDEGIWIT CTSEERRDSL NRFSTSCPSL ADPEVPYKYN DHHQSMLNIG EERDDQVEEE
EEEDDDEDEV DYPANDSEEL SQYPSVRNSA QNHSTNTASD MRNIDEGVKI RINDVTVDSS
EDNYDVLDPV MHSKDLYQET SPSAGTTGTL EENTPHKNVK PKQRRWSHHV MGMSVEKQQF
RNKLLAVSGK SMSLSSLDSA AEESEEEEGY IHKQLGNHKT SASLSPGSSS SLSAGTDLTG
MNPRHSWAGS YTTDIIGSPE ASGARNGMSP PDRPLSQGNS SIRSLTDIGL DLNSSNESQK
DAMAPNQTNV STTATSNPPM SVRTPKQKNV TLLQQSKMSV STPSLSSVKE GEVADCRRSG
TFNEGHITKE EAFTEKQSHV TIRKLVEEHD ALRKSQENGM TDEESKRKAR VSMIEFLNEK
KSVKQWGRRS VIETMREFWL PANFEEDEEN MEQEQKKEPK EEKKRKLSFM QKFGSHRQKR
KDKEGKKTHQ FVSVSFSNST SCDICGKTLA NKPAVSCENC SINVHDSSCK DSVPPCLKLK
KDKRPYRREI QERCPPPVGG QQGGPILKSS QSFVEAGSVP AGRVKQTSVS FSSLPNRNSS
PNDQLNAGRW SSGAYSQWRR VAAKLGIDKA IAEESQESLD GASISMGQDP STLSLQSRLR
NNLEDTVSLS MESLDEGAQV EFEDDEDLMI RGPEPEAWSV YVNKKEISKL GLSKKDVKRQ
DHLWEIVMTE KHHLRTLKIM QRVYSHGLVH EVGLPPELVD RLFPRLEDLI DISATFLQRL
QERQDEHPNK FVSQIGDLLI EQFDSPSSTR MVSAFGEFCS KKKEAEALYK DLFKQEKKFQ
NFIRKCSGNG LCKHHSIPDC ILLVTQRLTK MPTLIEAVIK KTQETNPDHA LLKKADMLAR
NILNAIDAQV DAKEKEQRLI EIYNKLDVRS TAVYKGKKFK KSDLLSNNRK LVYESTIAWK
TARGKTIDVL IVVLSDLVFF LQENNQKYTF FTQDNKASVV SLYKLLVREK GATRDNKGVY
VISQSKDTPE MYEFVCKSGE ERKQMINIVS AAIRNCPEED DDEGVPSESE EERKIREARA
QKVRECLSFL QRSQDQIREL LKDRLHAVFD MFDHQPKEEH LLQPYGQDED ANPAEWIDRA
AKEAERLSWL LQSGSTNLSR SVSSVGEHQS GSYTPPPVPK RSETFGGFEV SADTETVDSD
IVVDKMLDHL TKVTNNQFEC SIDSMSGAVP LNLDTGACVN SYDDRNIAHQ KLNDIEESRE
SVDTGESIEH GVYLQKKRYS VMGIGIEEGQ NLASSEEKLR VRRKSRSPLD WIKRKASLQV
TTSHELLGEA TKPFWSSRTK IAKMRRSSIL RHNSDAGEHK SVQASRSGPQ LRRVESFAGF
GQSDGSSGSV KRRPPPFPKD DDGSFSSFQS FNKDGGVDTD SAIASDTTTV SNSSSSKKLI
RRGSGNILVS HEGVYRPQRD PALQKLKRTS TFLSGLLPTR NAEKDDSPDV RHSDKSSDLG
SISEFSISSV SLIPPVREQA ACLEQILRYL AQAMHASIHQ NTRLERCKAH LVESNEKVEK
LTAETKQYQE RKGTFRHNQQ LEELRRLQSS INTERTDWEK TKERERMRLE AERETVEEHR
KDIEKQQAEM EQQREELKRQ RAAFQRQIDL FEQRQQQIQQ EQQKEQQQLL QLQQQQQQLQ
KQLSSGNMIK SGLKDVNSTS VKNDKFSTTG KENNSLDPTR LSPQGLVISH RRSASADWNK
DSNDKRATEG EAFEPMKEEY ARSLQEPLNR KTRSDDRRIS HHVFEGQNRR ADTMPSLGIS
KRDTRENLPI HLVSATNEQK LQGAALKQQF PHKLGSSNSS PSFSGIIPKK LASSSSSSQP
SSHNSQSNKS ASLKHNSSGG GGMLPMKLAE RSRSDSKERS QSMSSPQSAG KKDQSVIYF
//
