ID A0A1S3J8F9_LINUN Unreviewed; 1181 AA.
AC A0A1S3J8F9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106170987 {ECO:0000313|RefSeq:XP_013406516.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013406516.1};
RN [1] {ECO:0000313|RefSeq:XP_013406516.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013406516.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00034734}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013406516.1; XM_013551062.1.
DR AlphaFoldDB; A0A1S3J8F9; -.
DR EnsemblMetazoa; XM_013551062.1; XP_013406516.1; LOC106170987.
DR GeneID; 106170987; -.
DR OrthoDB; 5489271at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR047170; PTN12/18/22.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45983; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45983:SF2; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 28..291
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 205..282
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 396..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1158..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 131183 MW; 27E81C71039C0952 CRC64;
MSIREILEDF VRHTDSLDEK DDDGRDGFER DFAELKQRSL EYKNTYSSSA GQKLYNGVKN
RYKDILPFEY TRVPLQPLPG LTGSDYINAN YVKGVSGHNT YIAAQAPLPT SVIDFWRMIW
ENEVKVVLMA CNLREAGKTK CEKYWPELDR EVQFGDLLIT LTKEDHQSPD YTLRELEVRK
ANICKVVYQL HYTAWPDHGV PDHYDYILDL VAEAREKQQQ ETLPIVVHCS AGCGRTGTII
AIDYCWSLLK KGKLTKDFNL FNVIDEMRRQ RPSAVQTPDQ YWFVFMAVRE LFERHLRIIE
RHSYENVQVG EGSTYEKEDS YDPYENVDVF ESTASINQED DYAIPEPAHG VVQAAASPFK
GPSKPPQAAP ARIHPAEIAI EKTVAKLASK QADFLVPDSS GHVPRHPPEK GLGPSREERR
EEYVNVDIPK STMAETGKPL LKTVVKRDPL PVQGQTEVQK RDEYVNVDLP KRTSIKEMDP
MPAAKATVAR KPSNESRNLQ VADGVDQSSS YTIQGGTHVN AKVKSFEKTQ SSVDASSTRK
SSADTMQKGH QAVQDSSLLK GQNVTVIAVK GENQEGRIFD RKDPVSPVMP YAIGNVHLKE
NAHYEAVWPV QKEQNLPTQE AAHIQISSKE DDARSQSVSE LRQKLGSDLV LGSEQGKKSS
TSEDHHKLNP LQKLKNKISG EGNLKSADHK KKKSFDEDKD HSGKDQHSKP HHEEKGGPLE
HLKSAFQLGC GSCVSVDPAY AAVMQSQNAP LEKPPPHGVT PASDGFMKEL KAAQGGLRTA
EPENRASTNV NQQQHGVINK THPIPLPSGV RKSQPMAQPQ AVPYAVSNVQ LRNSTHETVT
GSHASSSDDI QPYASSSEFG LKGKTVQRGH NSDFEDEAAA PYSVTSEMGL FGRKKQENSF
PSKSSATPPV AHEYADPFLD SQSTVSESSG EYAEPYSTTR ELFGKRSSQN DARPPALIPK
IEETKEPNSL EYSYSFEHCK QMPLSSPKGF FDNSSVGGPN PKAPPRKKRS SQDGSPQGEG
QTYEPVLLKS SERDVNPPGS RENRPTEVKQ PFQRPRAVSE DDDKPPPIPT KSEGAFLDVS
QDVSEKPEES GPESGGKPKT TNVLEKLMSK VPMKSNKGRE PSLPSAGVST PAVFIPFKTD
SDEALFCPPS HHPFFKKVEF PHRNERKPQG PRPMVGAWKL P
//
