ID A0A1S3JED4_LINUN Unreviewed; 624 AA.
AC A0A1S3JED4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Netrin-1 isoform X3 {ECO:0000313|RefSeq:XP_013408521.1};
GN Name=LOC106172386 {ECO:0000313|RefSeq:XP_013408521.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013408521.1};
RN [1] {ECO:0000313|RefSeq:XP_013408521.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013408521.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_013408521.1; XM_013553067.2.
DR AlphaFoldDB; A0A1S3JED4; -.
DR EnsemblMetazoa; XM_013553067.2; XP_013408521.1; LOC106172386.
DR GeneID; 106172386; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF448; WING BLISTER, ISOFORM B; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 60..295
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 296..351
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 415..464
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 493..622
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 471..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 298..315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 415..427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 417..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 436..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 448..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 624 AA; 70625 MW; BCF25E45F8F6F45A CRC64;
MNTRGIKTWT LSRDFHTQTL LGVFLLLTLF SKGALASSSF LTMFAAQQNP PDPCYDEMGN
PKRCIPDFVN AAFGKEITAS STCGSPPNRF CQVSPSVDKF KAMHCDICDA KHPKRMHPPS
YLTDLNNPNN LTCWMSEPFV QYPNNVTLTL SLAKKFELTY ISLQFCSPRP ESMALYKSVD
HGRSWVPFQY YSSQCKEMYG KPPRGMITKA NEQEALCTDI NSNSPEPISG GRVAFSTLEG
RPSAYDFMNS PVLQDWVTAT DIRVVFNRLR TIDENVDKAK DNFYYSLADF AVGGRCKCNG
HASKCNINRD GTLACECKHN TAGTDCERCK PFHFDRPWAR ATDQKANECV ACNCNLHARQ
CRFNKELYNL SGRKSGGVCL NCRHNTAGRN CHYCKEGYYR DPTKPMTHRR ACKACDCHPI
GSLGKTCNQT NGQCPCKDGV TGITCNRCAT GYTQSNSPIQ PCVKASNSSA DSSLTTKTHQ
PKVTSPKPKP VSCDRDKCKA ASKRISKKKF CKYNFAVNVQ VITRENIGEW VKFTVNILSM
FKRSSSSKLR RGEEQVWIQL SDVRCKCPRL KVGRRYLLLG HDHQNTNMDG LVLDRRSIVI
PWKDEWQRRL RKFQRYERKG RCRN
//
