ID   A0A1S3JET4_LINUN        Unreviewed;       368 AA.
AC   A0A1S3JET4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Uridylate-specific endoribonuclease {ECO:0000256|RuleBase:RU367085};
DE            EC=4.6.1.- {ECO:0000256|RuleBase:RU367085};
GN   Name=LOC106172303 {ECO:0000313|RefSeq:XP_013408404.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013408404.1};
RN   [1] {ECO:0000313|RefSeq:XP_013408404.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013408404.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-
CC         ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA;
CC         Xref=Rhea:RHEA:67792, Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:17354,
CC         Rhea:RHEA-COMP:17356, ChEBI:CHEBI:83064, ChEBI:CHEBI:173117,
CC         ChEBI:CHEBI:173224; Evidence={ECO:0000256|RuleBase:RU367085};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936,
CC         ECO:0000256|RuleBase:RU367085};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245,
CC       ECO:0000256|RuleBase:RU367085}.
CC   -!- SIMILARITY: Belongs to the ENDOU family.
CC       {ECO:0000256|ARBA:ARBA00010168, ECO:0000256|RuleBase:RU367085}.
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DR   RefSeq; XP_013408404.1; XM_013552950.1.
DR   AlphaFoldDB; A0A1S3JET4; -.
DR   EnsemblMetazoa; XM_013552950.1; XP_013408404.1; LOC106172303.
DR   GeneID; 106172303; -.
DR   KEGG; lak:106172303; -.
DR   InParanoid; A0A1S3JET4; -.
DR   OrthoDB; 1329861at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR   CDD; cd21159; XendoU; 1.
DR   Gene3D; 4.10.410.20; -; 2.
DR   InterPro; IPR039787; ENDOU.
DR   InterPro; IPR037227; EndoU-like.
DR   InterPro; IPR018998; EndoU_C.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   PANTHER; PTHR12439; PLACENTAL PROTEIN 11-RELATED; 1.
DR   PANTHER; PTHR12439:SF11; URIDYLATE-SPECIFIC ENDORIBONUCLEASE; 1.
DR   Pfam; PF01033; Somatomedin_B; 2.
DR   Pfam; PF09412; XendoU; 1.
DR   SMART; SM00201; SO; 2.
DR   SUPFAM; SSF142877; EndoU-like; 1.
DR   SUPFAM; SSF90188; Somatomedin B domain; 2.
DR   PROSITE; PS51959; ENDOU; 1.
DR   PROSITE; PS00524; SMB_1; 2.
DR   PROSITE; PS50958; SMB_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endonuclease {ECO:0000256|RuleBase:RU367085};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU367085};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU367085};
KW   Metal-binding {ECO:0000256|RuleBase:RU367085};
KW   Nuclease {ECO:0000256|RuleBase:RU367085};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   RNA-binding {ECO:0000256|RuleBase:RU367085};
KW   Signal {ECO:0000256|RuleBase:RU367085}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|RuleBase:RU367085"
FT   CHAIN           22..368
FT                   /note="Uridylate-specific endoribonuclease"
FT                   /evidence="ECO:0000256|RuleBase:RU367085"
FT                   /id="PRO_5026370265"
FT   DOMAIN          22..66
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
FT   DOMAIN          68..104
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
FT   DOMAIN          116..368
FT                   /note="EndoU"
FT                   /evidence="ECO:0000259|PROSITE:PS51959"
SQ   SEQUENCE   368 AA;  41186 MW;  790AC4F3DE514AE1 CRC64;
     MGTLRRHVSL ILLSMLINAS ANEDFCDGRC GDSLDRTRSC QCNSACQRYG DCCEDYVDCC
     LVSDFCNGRC GAYIDGTRSC QCNSACQRYN NCCEDYVECC LSACNIEYRH CPVLITDDEL
     SQLAEELYDV DSNKAASSDV ILEDLGVQLF NYVNEASLLQ NPSYSLFLSL LDNYNPYTGQ
     LETLSSDELS EIDQYLDYIL TTPVMVTLKT FLKQKGYASS DSAYRGLLDD LWFQLYPRSS
     FGPVDSSGFE HVMVGELKTS SVTGFHNWFR FYQLEKAGSL TYKGFRSSVQ TSPQVLKVRL
     EWFGKSKPQS SFFLGTSPEY DMAVYTVCAL ARTNSRCPIK LAGKSVPIQT YDVAHKSGLQ
     IATSYSVI
//