ID   A0A1S3JGC5_LINUN        Unreviewed;       470 AA.
AC   A0A1S3JGC5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Acid-sensing ion channel 2-like {ECO:0000313|RefSeq:XP_013409196.1};
GN   Name=LOC106172835 {ECO:0000313|RefSeq:XP_013409196.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013409196.1};
RN   [1] {ECO:0000313|RefSeq:XP_013409196.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013409196.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   RefSeq; XP_013409196.1; XM_013553742.1.
DR   AlphaFoldDB; A0A1S3JGC5; -.
DR   EnsemblMetazoa; XM_013553742.1; XP_013409196.1; LOC106172835.
DR   GeneID; 106172835; -.
DR   KEGG; lak:106172835; -.
DR   InParanoid; A0A1S3JGC5; -.
DR   OrthoDB; 3414706at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        71..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        438..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   470 AA;  52554 MW;  BFE481D57067BAEA CRC64;
     MDNPVRTDKE DAFALKEKAN TGRNSPVTGR TTRRRYPCRC AESTVNDFAL SVNCQGLPQM
     FGANSGIVRR VVWFILISGG LALAIFQIVD RIEFFLSKPV AIQSDVVCPT SALFPTVTIC
     NFNAIRLSRA ESLHVKGLVE DVYPLSRTIS PNFTGYSFAR YDWKSFFESV AHEASAIKVC
     IWQGTKCTEQ NFTTTFTDMG VCYSFNTGDG AALLRSDSSG SQYGLSLTMD AMQHEYFRGF
     AGIGAGYKVM VHDPREPPLM ANLGFSVGVG MHTLAALKMY NISNLDTENW GKCRRNMTLK
     YYDYYSHSAC RLECLTDFII NKCKCQFINM RAPNVPICDP KQIFDCYEPN RNVFIKEKGQ
     CQQECPIPCD SITYDVSLSQ APLSDYHTGT FTVNNVKPDY IKNNFVQLDI FFQGISYERL
     EQYPAYNPFA LGCDVGGAMG LVLGASALTL CEIMDFVIVW ALRGKGKRLC
//