ID A0A1S3JGD7_LINUN Unreviewed; 447 AA.
AC A0A1S3JGD7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neuronal acetylcholine receptor subunit alpha-2 isoform X1 {ECO:0000313|RefSeq:XP_013409423.1};
GN Name=LOC106173008 {ECO:0000313|RefSeq:XP_013409423.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013409423.1};
RN [1] {ECO:0000313|RefSeq:XP_013409423.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013409423.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013409423.1; XM_013553969.2.
DR AlphaFoldDB; A0A1S3JGD7; -.
DR STRING; 7574.A0A1S3JGD7; -.
DR EnsemblMetazoa; g15325.t1; g15325.t1; g15325.
DR EnsemblMetazoa; XM_013553969.2; XP_013409423.1; LOC106173008.
DR GeneID; 106173008; -.
DR KEGG; lak:106173008; -.
DR InParanoid; A0A1S3JGD7; -.
DR OMA; HTENEFA; -.
DR OrthoDB; 3015258at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF865; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_013409423.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..447
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010197142"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..247
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 256..396
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 447 AA; 50949 MW; 42D77DA077BDE58B CRC64;
MAASNRSKGF WHIPMLLEAV ILLVISQVFC ADNSSFITQE RRLYKDLMKN YVKSIRPARN
ASDNVTVRFG LSILNIADVD LKTHTLSLNV WADEVWNEPQ LSWDPNLYGG VKSLQIPAAA
LWKPDITLYN NFGDTYTQEA NAVVLNTGVV YYVPYMRLKS YCSYDLTRFP YDTQECTLLF
GSWVYDESML DIQLNGNSSE NYVSLASFRE HHEWNVTMAS GRRDVIKYPC CAHGFAHLTF
TLTMKRLTTY YTYVYVTPCM LLNLLLPLMF LLPPETRQKT TLGIGIFIGY SILLLMLEMT
LPSAFSYVPL IAMVYVTGMI LVTISLGIGV LTTCCWEYAP RAKREMPPLL KTVFLGWLAR
VLCVNRDSYT PHQPDVSTIQ QMSQLQMHDP VQELENGAFD VNDRYNVLTV PRVHDVISAD
WRALAVTVDR LLFVVFLVVN LVLTIVL
//
