ID A0A1S3JKH7_LINUN Unreviewed; 243 AA.
AC A0A1S3JKH7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN Name=LOC106174079 {ECO:0000313|RefSeq:XP_013410925.1};
GN Synonyms=EIF6 {ECO:0000256|HAMAP-Rule:MF_03132};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013410925.1};
RN [1] {ECO:0000313|RefSeq:XP_013410925.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013410925.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC association with the 40S ribosomal subunit to form the 80S initiation
CC complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_03132}.
CC -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC {ECO:0000256|HAMAP-Rule:MF_03132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}. Note=Shuttles
CC between cytoplasm and nucleus/nucleolus. {ECO:0000256|HAMAP-
CC Rule:MF_03132}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC Rule:MF_03132}.
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DR RefSeq; XP_013410925.1; XM_013555471.1.
DR AlphaFoldDB; A0A1S3JKH7; -.
DR STRING; 7574.A0A1S3JKH7; -.
DR EnsemblMetazoa; g16087.t1; g16087.t1; g16087.
DR EnsemblMetazoa; XM_013555471.1; XP_013410925.1; LOC106174079.
DR GeneID; 106174079; -.
DR KEGG; lak:106174079; -.
DR InParanoid; A0A1S3JKH7; -.
DR OMA; CISTNDY; -.
DR OrthoDB; 5473211at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042256; P:cytosolic ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd00527; IF6; 1.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR NCBIfam; TIGR00323; eIF-6; 1.
DR PANTHER; PTHR10784; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR PANTHER; PTHR10784:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR SUPFAM; SSF55909; Pentein; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03132}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03132}; Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
SQ SEQUENCE 243 AA; 26295 MW; 1CFF209E05C0F9B1 CRC64;
MAVRVQFEGN NEIGVFSKLT NAYCLVAIGG AENFYSVFEG ELSDTIPVVH TSIAGCRIIG
RLTVGNRHGL LVPNTTTDQE LQHIRNALPD SVKIQRVEER LSALGNVIAC NDYVALVHPD
LDKETEQILE DVLKVEVFRQ TVADNVLVGS YCTITNQGGL VHPKTTVEDQ DELSSLLQVP
LVAGTVNRGS DVIAAGVVAN DWLAFCGLDT TATELSVIES VFKIGDAQPS NITTEMRDSL
VDR
//
