ID A0A1S3JKS3_LINUN Unreviewed; 648 AA.
AC A0A1S3JKS3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=LOC106173935 {ECO:0000313|RefSeq:XP_013410730.1,
GN ECO:0000313|RefSeq:XP_013410731.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013410731.1};
RN [1] {ECO:0000313|RefSeq:XP_013410730.1, ECO:0000313|RefSeq:XP_013410731.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013410730.1,
RC ECO:0000313|RefSeq:XP_013410731.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR RefSeq; XP_013410730.1; XM_013555276.1.
DR RefSeq; XP_013410731.1; XM_013555277.1.
DR STRING; 7574.A0A1S3JKS3; -.
DR EnsemblMetazoa; g15931.t1; g15931.t1; g15931.
DR EnsemblMetazoa; XM_013555276.1; XP_013410730.1; LOC106173935.
DR EnsemblMetazoa; XM_013555277.1; XP_013410731.1; LOC106173935.
DR GeneID; 106173935; -.
DR KEGG; lak:106173935; -.
DR OMA; INEFFAY; -.
DR OrthoDB; 1333063at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 454..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 490..509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 558..581
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 216..288
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 295..393
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 398..613
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 70321 MW; 51FEB2F7FC1B501B CRC64;
MPSESPNSKK PLVDVPSQAS MQPLMKSDVS VNIPEGYASE GYLGSKATVV SSLDGSNDEL
KVVIDNGPVK GGFDSDDSGS AESDDVISNC ARLEAVQGAV DTFLEEHKRT LEIIALVLLL
IGYAIYFVWA LVLDFERATA LFVITLLVVI SVAYALIKKQ IGGWMNTRIF KPVQKFGNSN
RRVLKWVSAA VLLACFITFV IVDIKPAPKQ FISLGGLALF VLLMFVFSKH PSKVDLRPVV
WGFALQFLFG ILILRTTWGY DAFRFLGKEI NQFLKYTDYG SEFVFGKLYE NHFFAFKVLP
VIVFFSCAIS ALYHVGAMQF IIGKIAWVMQ VTMATAATES LSCAGNIFVG QTEAPILIRP
FLESMTKSEL HAVMTGGFAT IAGGVLAAYI LFGVPAEHLL CASVMNAPVA LAVSKLFYPE
TEESKTKKFD QIVMEKGTER NLIEAAAAGA SQSIMLVANI AANLIAFLAM LAFINATLSW
FGGMVGYPEF SFQMICSYLF MPVAFMMGVD WEDCSFVAEL LGIKIFLNEF VAYEELSKYI
HNRENCTFPQ ISVRSEVIAT YALCGFANLS SIGIQLGGIG PMAPSRKGDL AKIAVRALIA
GTVATLMTAC IAGFLTPVDV SNVCLNGTLA ANFSSIANST VNVTIVTL
//
