ID A0A1S3JMV3_LINUN Unreviewed; 945 AA.
AC A0A1S3JMV3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Proto-oncogene vav isoform X6 {ECO:0000313|RefSeq:XP_013411705.1};
GN Name=LOC106174611 {ECO:0000313|RefSeq:XP_013411705.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013411705.1};
RN [1] {ECO:0000313|RefSeq:XP_013411705.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013411705.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013411705.1; XM_013556251.2.
DR AlphaFoldDB; A0A1S3JMV3; -.
DR EnsemblMetazoa; XM_013556251.2; XP_013411705.1; LOC106174611.
DR GeneID; 106174611; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 4..123
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 207..387
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 420..530
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 541..592
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 634..699
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 758..855
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 873..934
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 704..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 108705 MW; 40CE3CE96D84DD38 CRC64;
MATRDLWRLC ADWLIRCEIL PRDHRVMFPN AEIFDLAQTL RDGVLLCHLL NTLSPGAVDM
KDFSQRPQMS QFLCLKNIRT FLQTCKNKFG LRESDLFDSY DLFDVKDFAK VLNTLSKLSK
SELALASGID GFPQDNSSIQ VEHDYYNTLE ELATELPDED IYSAVTTVEE GEQEIYEDLC
SLRGRTTRRR KERERDQLEQ GFEPKTKREH CLKELIETEK NYVEALQMIK TFFIHPLKNI
IPSPNHELIF KHIEGLGNIH TAFQSDLHQA VRRSSAQALG DCFIKYKPQL LLYGDFCSNL
PQAQERIDDL CRKNEIIRVA VEECQRKANE GKFRLRDLLS VPVQRVLKYH LLLKELIKQT
DKKSPDRTFL EKALEAMQDL SLYVNEVKRD NEQLQLIQEI QDSIVDLQMP EKTSLKDYGR
LLKDGELKIK SHEDNRLKTR YIFLFDKVML MCKSRTMEKF LWGETYSYKN ALVLAQHRVE
EGVPAGRPRS EKWGHVFLLS ENKNSVAYNF YAKTEEMKMK WVDAIKMALD NTNPANAREK
GHDFIMTTFE EPQTCSECKK LLRGVFYQGY NCHRCKQSVH KECIQKASKR ECHISNGPAP
ELPPRPIDRS STVYNHRSAS VSSAHSRGLP AKPSLGIKVK AVASYTGTPA PPTNKGQALK
FEQGDVIDLI SNDNVQWWEG RLHGKEGFFL KSYVEEYRRP FQRGPSYLHH DVRPPSPLHN
DENQSPIGSP LQRSPRPASS ASQKHPYINL ANLEGYPWYV GEMSRESAMV KLEHHPSSTY
LIRESINPAR RGDYALSVKY DNNVKHIRVM RTQEGSFYLA DCRFFRSIPE LVDYYQKNSL
AYSFPELDTV LSIPYNESVR QNAVFHPAPR ETPALGYAVA SFDYAATATN QISLTKGDRI
KIVSKQGEDR GWWKGELRGK IGYFPCAYVD EEEDAADGNS ASSPR
//
