ID A0A1S3JND7_LINUN Unreviewed; 587 AA.
AC A0A1S3JND7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC106174454 {ECO:0000313|RefSeq:XP_013411474.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013411474.1};
RN [1] {ECO:0000313|RefSeq:XP_013411474.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013411474.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013411474.1; XM_013556020.1.
DR AlphaFoldDB; A0A1S3JND7; -.
DR STRING; 7574.A0A1S3JND7; -.
DR EnsemblMetazoa; XM_013556020.1; XP_013411474.1; LOC106174454.
DR GeneID; 106174454; -.
DR KEGG; lak:106174454; -.
DR InParanoid; A0A1S3JND7; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06648; STKc_PAK_II; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF4; SERINE_THREONINE-PROTEIN KINASE PAK MBT; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|RefSeq:XP_013411474.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transferase {ECO:0000313|RefSeq:XP_013411474.1}.
FT DOMAIN 11..24
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 315..566
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 94..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 345
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 587 AA; 65969 MW; A4B0912979ADAD02 CRC64;
MFAKKKKRPE ISSPINFEHR VHTGFDTLEG KYVGLPPQWA SIIGNARRPQ PIIDPMEVTS
TEAAPHKSII RGGDQRSQIS NGYQTNAGNI TVARSNSLRK SPPTMRRGDL MRGENVPPTV
HESGQMSPGG YGGGYRQDYP PPYQPNDPYG SYPRNTRGEY PGEHRDMGYP GGPDPRDYDY
HQQQRDGRAP PPRRDDPHYH HNQYPPNTAN GGNSTLPRQQ PQPQHMGKPQ MPTGPQQYDR
GSPPNKQPHQ QHSPMQPSPP MGVHQSQSPS PLPQSGGKPA QGKPQPNPET QRLSHEQFRA
ALQMVVSPGD PREILDRFTK IGEGSTGIVC IAAEKKTGRQ VAVKKMDLRK QQRRELLFNE
VVIMRDYHHP NIVDMYDSFL VEDELWVAME FLEGGALTDI VTHSRMDEQQ IATVCKSCLK
ALAFLHSNGV IHRDIKSDSI LLSHDGKVKL SDFGFCAQVT PELPKRKSLV GTPYWMAPEV
ISRLPYGPEV DIWSLGIMVI EMVDGEPPFF NEPPLQAMRR IRDMPPPKLK NPHKVSPRLQ
GFIEKMLMRD PAQRATAFEL LQHPFLRQSG PSSCLVPLMR SFHHSPC
//
