ID A0A1S3JNR4_LINUN Unreviewed; 1031 AA.
AC A0A1S3JNR4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Double-stranded RNA-specific adenosine deaminase {ECO:0000313|RefSeq:XP_013411771.1};
GN Name=LOC106174658 {ECO:0000313|RefSeq:XP_013411771.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013411771.1};
RN [1] {ECO:0000313|RefSeq:XP_013411771.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013411771.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013411771.1; XM_013556317.1.
DR AlphaFoldDB; A0A1S3JNR4; -.
DR STRING; 7574.A0A1S3JNR4; -.
DR EnsemblMetazoa; g16520.t1; g16520.t1; g16520.
DR EnsemblMetazoa; XM_013556317.1; XP_013411771.1; LOC106174658.
DR GeneID; 106174658; -.
DR KEGG; lak:106174658; -.
DR InParanoid; A0A1S3JNR4; -.
DR OMA; NARDINP; -.
DR OrthoDB; 118472at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19902; DSRM_DRADA; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF145; DEAMINASE ACTING ON RNA (ADAR)-1, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF02295; z-alpha; 3.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00550; Zalpha; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50139; Z_BINDING; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 1..63
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 92..157
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 344..411
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 553..621
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 693..1030
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 146..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 112861 MW; 3C483B3AA7F21A7B CRC64;
MMANDGQILN LFQQRAGQDI SPTDISKALK ITRKEVNQVL YGMKRRNVLQ KVSDQPPLWR
MEGGNPDTST FDSYVGGPMQ SVRYHCHHDH KPYSRPNLTD QIFEVLKKNG SAMKTIDIAR
AVGLHSAKDV NSTLYRMEKE GLLKKANDQP PSWMVLRSGE NEGTSKHRPH HSVPGMSSFQ
NNPELDSVSY PQHELMGETT PPGPDEISDT LEVDTDDSSV PESSSAQHGS QTDLANFDMS
DAEQNTTPDS NNKANLEMQS NPPGGGDFSL SKPTTRTGPP LSPAELLKGA TFGDPRYRMA
AVSGASSAPG APPPPSTLNV SYVTDPTSGQ SSFMREISKH QSPQIQPQEL QKNILEYVTR
QQAPVIALDI AKGIGLSTAK DVNPMLYQLE KQGLITKVDQ AYGCPKWGVG SAGKEVTPPL
SLTPSPAHSQ ILKPSKFSPE SLLFSRPNIP TAPMTAKYPG TEKVTGPPPS PMDLIRQTTT
WGKGANPTFT PNTSTSVKTP DSINLDNQAK LLAGLNVRPS SVEQPAAFAL SEQQPQSSFP
SLNSDSFAAL NKNAVSALME YAQSRKTTAT IEVLGQRGPP HKPQFEMAAF VGTRRFPSVI
ATNKKDGKKD AADLALRQLM AEGSYQVASA TPAVDIVQQL TSTSSTHFDK IAALSHQAFN
LIAATVTENM SGKKVLAALV MKKDPTDTGT VVSLGTGNRC ITGPMLSMVG DTVNDSHAEI
ITRRGFLRFL YKHLENYSPN SPDTILEVCE ESGKMKIKDG ITFHLYISTA PCGDGALFSP
RDATGQAKEE DNIKEHTPTF TNQLQGVLRT KVEDGEGTIP IEPGFTGLTW DGVMRGERLR
TMSCSDKLCR WNILGMQGAL LSNFLEPIYL SSLTLGLLYD HGHLSRAMCC RLAKGEPDLK
EVLPEGYRLN HPHLGRVTMY EAPRETQKTK SVSINWCCFD RKAEVTDGTR GMVEMGGKIS
VSQLSKGELY KSYRNVCAKF NRTDLLQAGS YYEAKQMAAQ FQESKQIMYQ KFKKNKFGTW
VKKPQEEKMF T
//
