ID A0A1S3JP78_LINUN Unreviewed; 605 AA.
AC A0A1S3JP78;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Endoprotease bli-4-like {ECO:0000313|RefSeq:XP_013412170.1};
GN Name=LOC106174937 {ECO:0000313|RefSeq:XP_013412170.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013412170.1};
RN [1] {ECO:0000313|RefSeq:XP_013412170.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013412170.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013412170.1; XM_013556716.2.
DR AlphaFoldDB; A0A1S3JP78; -.
DR STRING; 7574.A0A1S3JP78; -.
DR EnsemblMetazoa; XM_013556716.2; XP_013412170.1; LOC106174937.
DR GeneID; 106174937; -.
DR KEGG; lak:106174937; -.
DR InParanoid; A0A1S3JP78; -.
DR OrthoDB; 2996461at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 317..452
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 451..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 30
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 70
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 249
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 605 AA; 65073 MW; ABF864DE84546358 CRC64;
MGSGRNLDSK ITQAWCMGKT GQNVLVAVVD DGVWSRHRDL KDAVNLDKSY DYQRNWAGSS
DPGNLWSDNH GTSAAGIIAA APNGVCGVGV APGAKIAGIR LYGDNPTTDL MEANALTSSM
YDVSIYSCSW GSARTGFDLK PLGARAAEAL QRGATQGRGG RGSIYVFASG NGGSNGDSCA
YDGFANSIYT IPISGVTADG EMMSSGEQCG AIMATTFTRD SSKDWTPNRI ITPGTTGRSS
CTSDFGETSA AAPLAAGIIA LALEANPRLS ARDVQHLIAE TANNNFGRGN LWSWNAAGKK
VSRAFGFGLL DAEKMVRYAE KWRSVPTLKS CEATLRNINR TIPGTVTLNL PSWKCSVNHV
EHVQLYVLTK FTKRGFVKVN LRSPSRTESV MIPGRPNDQW SAYLELTVSS VQFWGERGTG
WWEVVIDSLY PNQGHSGTVY DVKLVVYGTQ QSPPRQTPSS VNSGCANQQQ VTLPPATKPT
VKPTQPPVTQ LPVTSPSCSC KTLTNPSWGS NLKVQLQQGS EIYEIQCPQN IVSSDIMIDC
QMKKKTYTVQ GSSCGCDFSR WSYNGASWWV TVGGEKFLIS CTISSPWTMV SYPCRGIRNS
SPLIG
//
