ID A0A1S3JPS8_LINUN Unreviewed; 451 AA.
AC A0A1S3JPS8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=HMG box-containing protein 1 {ECO:0000256|ARBA:ARBA00017229};
DE AltName: Full=HMG box transcription factor 1 {ECO:0000256|ARBA:ARBA00030708};
DE AltName: Full=High mobility group box transcription factor 1 {ECO:0000256|ARBA:ARBA00030026};
GN Name=LOC106175083 {ECO:0000313|RefSeq:XP_013412362.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013412362.1};
RN [1] {ECO:0000313|RefSeq:XP_013412362.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013412362.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional repressor that binds to the promoter region
CC of target genes. Plays a role in the regulation of the cell cycle and
CC of the Wnt pathway. Binds preferentially to the sequence 5'-
CC TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by
CC interaction with RB1. Disrupts the interaction between DNA and TCF4.
CC {ECO:0000256|ARBA:ARBA00025095}.
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DR RefSeq; XP_013412362.1; XM_013556908.1.
DR AlphaFoldDB; A0A1S3JPS8; -.
DR EnsemblMetazoa; XM_013556908.1; XP_013412362.1; LOC106175083.
DR GeneID; 106175083; -.
DR OrthoDB; 2882425at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd21988; HMG-box_HBP1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR003652; Ataxin_AXH_dom.
DR InterPro; IPR036096; Ataxin_AXH_dom_sf.
DR InterPro; IPR039655; HBP1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR15499; HMG BOX-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR15499:SF3; HMG BOX-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08517; AXH; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00536; AXH; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF102031; AXH domain; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51148; AXH; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 165..311
FT /note="AXH"
FT /evidence="ECO:0000259|PROSITE:PS51148"
FT DOMAIN 371..439
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 371..439
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 50486 MW; 75AA7868955ABCCB CRC64;
MGRHKVDDDE DDDMLEVVTT TRSAKHTPPS LRLDSSDSSP IDVVSTTDGE DSNANHVTVQ
PVSTSNWLEQ LAEIATGPKS PLIQKQSTAE RSPTKSFLEC SLHSYARPPR TRSPSPVRGN
TRSLSSSASE SHFKYNCDES ESRVSSSSPF PSSPLDDSYG SSGSWSHSWP SAVWQCFIQG
TRIRFTTGNK TEWQLAEDLA NTSYLTAQAS QDNLPKDSNY APNGLTLLHI EECKATEQRP
VPFLRLRFSS DIPTQSEIIA ECALDHPFFV REKGWSSFHP SMTVEHYGIP CSELEVGDIT
LPPSHPEATF TVDVFESFKS YDFTPMDSSA VFTLSTMAKK SKESDSWSPK SSPTTSPNRK
RLSKPESPSK AKRPMNAFML FAKKYRVEYT QMYPGKDNRA ISCLLGERWK KLKSEERKAF
SLEAKMLADQ HKKIHPDCWK RKRSTSTGSL E
//
