ID A0A1S3JRL1_LINUN Unreviewed; 3150 AA.
AC A0A1S3JRL1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Uncharacterized protein LOC106175255 {ECO:0000313|RefSeq:XP_013412619.1};
GN Name=LOC106175255 {ECO:0000313|RefSeq:XP_013412619.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013412619.1};
RN [1] {ECO:0000313|RefSeq:XP_013412619.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013412619.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_013412619.1; XM_013557165.1.
DR STRING; 7574.A0A1S3JRL1; -.
DR EnsemblMetazoa; XM_013557165.1; XP_013412619.1; LOC106175255.
DR GeneID; 106175255; -.
DR KEGG; lak:106175255; -.
DR InParanoid; A0A1S3JRL1; -.
DR OrthoDB; 2970981at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.30.310.200; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR032171; COR.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45752:SF199; LEUCINE-RICH REPEAT PROTEIN SOC-2 HOMOLOG; 1.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08477; Roc; 1.
DR Pfam; PF13676; TIR_2; 2.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51424; ROC; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1000..1032
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 1975..2148
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2777..2802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2843..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3062..3095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..836
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2783..2797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3062..3078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3079..3095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3150 AA; 357881 MW; 6AE4463B057E233C CRC64;
MAEEERNEFE DILSEENVNN QEDFEDDLYN LEEEYVEGEE ADDDDMYGET EEPEELQAQG
NPFANIFSGF GDMLNVAAQE QKYPQSQQVQ QQAATANLIQ GFSNVFTEFG DLAGAAQSGE
RGNRRVDPSE LMFTKKNLKK VDLNQGRRRQ GIGFKEFYED FNQAEYKKFP EEAIHYLPVE
SIVKVIERTL PPPSVLDFKG LDMMTDFVFE YLMRRNEEES LEAAFTVTAI DCSGCRYLTD
EGILRMVHTF KYLKEVVLDA CPLLTEMSLL YLLDLEEIEV ISMKATAVSV VTFSLKDHPQ
LKHVNLEGCP LHTPFPSNRG ILHSITSGDI GRESELRGYL RELTANHKVM MNMVVLNMYT
PFGFTHWLET GEKKESQEPF HYLPACEVNF PINTPDGRSW DHASYNILEI SEGYQGFEHL
FLSESNLIVI PFLLSKFSSQ DEVQKWILSR HIQLSKYKPL QIVFACISDG RKEEKDKHPD
DSAVEKLFRS WWPDVLLEKV LQDEEFLLAP GTVQNFKFRC QQEHMDYEIL RMNRVAPSII
NLNLDEKGCV QQFWRKMAQL VRFYPRVNWI SSPELIAVTG AVQRLGTKQG IWAFSELYQA
LLADLEGCKL SSSVEEKSPS SAKIGEEEDT PFDTGPTYWQ YQKAIERMCK QGQCLYFPDM
RHQPVIIDFS WLKTELNKIV SHGDGKIPYD QEKMSDTKTA MLFKLLEKCG ILIQRPQQYL
LVPKLPAEPD IPMEYCWSDC PDSNEVQLSK GCVIVEDIPL GFFPVLLREC SKIAANPVLW
QNGLLAQHGA VTLLIERRET TGYELEEFLE PIRLKTPMKK GPMKKKGGKK KAPMKKAPIK
QANSKLKSSL LEDDDDDDEI EAELKAKALP EHTNIIYIAV RATKMFAEEE VRNQHALMSC
LWSTLLTYVT IMKYVCQKFK VYCQFLTPCP HSETCNSRTK FYQHNMLSNR DATNVVSRLK
CAQCKTDVKV EEILGPNDFS FVKPGGIAPT HTLDQVKFDA SPHVDYSRCF LCGNCAYEGI
DCPQNGTHGE TIYHCGCQRT AQMCSKCGVC TRCTKYLNKV QTALQPGLGS SRPFTMIEDI
NESSVISVEN LSRGNFISNR RLNVQSGTKW AAIDPVHFNF FEVTLLPAEM ERNKVTVGLS
KVFGKPLLEY HLQTGVIADH EETGVKEHKD GKWIVSEACT VRVQMRFDRD DQCKAMDTEK
VKIEISKAGE VIYTKKTRLQ RLCGTIGFHG KGIEVFVNAP GIKEAELTPS RRIKEEMLVE
IKDPATGVHH LAELSSSTHD NQLYTAVMKP EGIESFNISP YSDRLFPLYY SYYNKEPNDY
WTEALHEDCP QCKGKNEEKA SSCEFCGTSL KKMELISADL SEEDLNSRRA PIWLFSETQR
TNMKPYYSSK TDGRLEKWCR NFLQGTAKTA CTVAQNLPLV EEKIFAESDF NYSGVVGVII
PNLVNQHLVK MLPHVRQEAL TKGTERKLHQ LCYSRGDAGE MLKVRADYKL PKEEDGKYWQ
LHLVDSPGIE VPEDNLQGML AVLIACHAIM GSQKVDLPSH KKLLPDLDIT EDEAEELIQT
VIHLCTQSLM MTMLYHEVNG FGQYVLAKLL PDHAYIFKDE ITTFNEGGIL HEHETMTGDT
HLLCKAHLNC YLLEAGLTEF PMEKFQIDGT SYTRLIRSLR IPQNDIKALP EDFFPSFPSL
VEFDVSHNKL SILPKGIGKC KKLCGINVKK NNLQNLPEEL LELKDQPLRL EISENPIHSL
PEVICHLENL QRLLANNLLL TSLPENFGNL KNLNYLTLKH NCLQVLPSSF KNLKKLKSLS
LEGFPWFKHK PNGFLSQEDF GEFLKGTYAD KWLEMHKEDK ASLYEFFDED SNGLLDEKEI
AKLNACLFHI FPRFRGTEEE SGIPAEILEL ENLEYLDLQF QGITHIPDAI SKLHKLQELV
VSFNPCLETI SPLAGRLPLK RLVLDECPSI RTPPKEIISK GFQTIYAYLR RLISGSVECK
RTKLMLVGLG GVGKTSLVKA IMSGGGVGET QEAIPQVTDG IDICTWTVTR EKETVSYSVW
DFAGQTVYYN THQFFLSDRA VYLLLWNIRQ GHEHAGLDFW LNSIAVHAPK APILVVGTHL
DQVSKVEIPV EEMQQKYSQI KGFHFVSSHS GQGIKDLQEM LLDVTLEQPY IGEQIPQVWL
NLEKEIIKLR TTESVVSYVS LEDLALTKSG IYDKSEVSQA VQFLHELGSL QHFDNNFLKS
HVVINPQWIV DVMSCVVSVN DSHIKDGYFN HTDIPKVWED YPADLHWWLL RLTEEYDLTF
QLPDKPVNLV PCLLPERQPP FDWPELDREN GEREAKMIYK FDYLPAGLFN RAQVRLYEFS
DSSVIWKRGS RLKKNDHIAL LTQFRDSELH VKVQGTTPEN VLFLVHEVFE GLITESFQGV
VYDYLMPCPD CSKAHARDPH MFSASSIRRA TQLKAPFLQC TKYFHVIPLT DLHSMMPPES
STDYDLQLVQ TVRGLTDLRK DMSADIFISY CAKDVPKKSE KRVAPVDVCR DLEEAGYRCW
FQEDPSSQSL EVTAIALRDA RVFLACISDN YIEDQDCCAM FKYACTTLRK SIVLVVLGDS
MNWQTSQIGL LVAGEVYVNM QQKDKYTSKL EELAKKLDMN TLLKKDEAID YPPVFISYAW
ANSARAVELG TPEKEGAAGF GDPRDYKDFL EKNGIKCWLD VEQVGANGLF EDIAVGLQNA
KLVVACISDQ YAESTNCNME FRFAKTALNL PIIVVTVGRG QMWRKSEVGM LSINYPVVSH
DDTDQLLKLV KENLPSEVQQ PVSNETKEKK KEKEQANQQQ KNTSFQELYE LAQRKFLRQV
AKLADSFNME AYPRLVVIDH MATEETEEGE KESEKENSKD AEKDEEKEKD EERKLSTPHT
FSKIKKEHPH GQKHCYRVLC EHEQGWHIAG DPIPAPNMND TFLHKLIPYL ARIMAIVKHS
KHITLNCISG EEGEQFLKWL EETPRNAVSE WQDVYRDLLQ EVLKADKDST MAGLARCHLP
SGKVAWLCEG HRSQGRITVL SSTGSSAVSA PDAGKENFML KALMAPDNQL TLKYKAHNET
QMAAAMKDKK KAETTQKPKS GKTARPSETA PPSVNPLVAA TANAMTLDAV QRTAATANNS
SRTKARFKAA GIAAAVAGQK RNSSQTCVIL
//
