ID   A0A1S3JS14_LINUN        Unreviewed;      1114 AA.
AC   A0A1S3JS14;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Ubiquitin conjugation factor E4 B {ECO:0000313|RefSeq:XP_013412896.1};
GN   Name=LOC106175438 {ECO:0000313|RefSeq:XP_013412896.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013412896.1};
RN   [1] {ECO:0000313|RefSeq:XP_013412896.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013412896.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC       {ECO:0000256|ARBA:ARBA00007434}.
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DR   RefSeq; XP_013412896.1; XM_013557442.1.
DR   AlphaFoldDB; A0A1S3JS14; -.
DR   STRING; 7574.A0A1S3JS14; -.
DR   EnsemblMetazoa; XM_013557442.1; XP_013412896.1; LOC106175438.
DR   GeneID; 106175438; -.
DR   KEGG; lak:106175438; -.
DR   InParanoid; A0A1S3JS14; -.
DR   OrthoDB; 1554at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   CDD; cd16658; RING-Ubox_UBE4B; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR   InterPro; IPR045132; UBE4.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR   PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF10408; Ufd2P_core; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT   DOMAIN          1041..1114
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REGION          1..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1114 AA;  127795 MW;  DA140833BAD60E0D CRC64;
     MSELTPDEMR RRRLARLGAS PASSPGGGSV SPQTPASLGA SPSLRTQAAS STQPSPSETP
     MSVDQSASET SNMETDDSSC EKSAQSQVDV DSGIETNMEV DDEPRAETKR KRDISVSEAS
     EEQTIAAICR LFIVSWKERS EETLYLPDLA ESCSGSENGY EDYQDLISQI LMEVLTVMSQ
     QSKNPMLSLK PPKLAGSPSK YGASPGAGAM LLHERPTRDF PRLKFQPEDS KEVEMLKYLL
     DCFDRCLNEE RLSSKRSRVP PLSTAIEETR TQCVNMAALV LQGVLTHPRS PARPSLLLPF
     LLNHNLPAGF LEMLVKQTSG CQRSFKQVFA PILQGLYNTI KRLSFDEDDY RQPILVLRQL
     CDIQTFGKQK PVCSLIIQLD NWLPAGMTEA EGMELQKLAF LGPFFALSVF AEDNTQVVEK
     LFANKEMPPD SIRLVHQRLR SEMDFARNEL FEIVHTFLRN VDTRDSCLNF ITAVIQRNLK
     RAQIQADERL LCGEGLMLNF LTVLQKLSRP IKLEKVDPFY LFSPNARVNI SEEARLKCTT
     QDSTQWIEEL NKDTSHIWQD AKFPTECYFL TLHSHHLSIL PITRKYQRRL RAMRDLTRMI
     EELENHEPQW KHLPTVASRN RELLKRWKSQ ERRLQRGKMC ADAAVFQESL LVGTLQFFET
     LVQYLLRLVC PSYPRISLPL PQEVPMLFAA LPEYYVEDLA DFFLFVIQYT PHILETSLTH
     IKDLADFLIV FISSSHYIKN PYLVAKLIEV MFVLNPNVQP RTEKTSDMVL NNSLALDNLS
     PALMKFYTDV ESTGASSEFY DKFSIRYHIS IIFKTLWENP AHKGKLIEEA NSGKQFVRFV
     NMLMNDTTFL LDESLDTLKS IHEAQELMEN KAEWGKLSRE QQQSKQRQLA QDERQCRSYL
     TLGSETVEMF YYLTRQIQMP FLVPELADRL AAMLNFNLQQ LCGPKCKELK VKNPDKYGWE
     PKKLLDRLTS IYLHLNNCDA FAQAIANDER SYRKELFDDA VARLKKACIK THTEIAQFQQ
     LQSKVEKLLV EKHKEETDFG DIPDDFRDPL MDTLMTDPVI LPSGTVMDRP IIQRHLLNSS
     TDPFNRQHLT EEMLIPATDL KKRIEQWKRE KTKK
//