ID A0A1S3JWQ1_LINUN Unreviewed; 489 AA.
AC A0A1S3JWQ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Disks large homolog 2-like isoform X3 {ECO:0000313|RefSeq:XP_013414732.1};
GN Name=LOC106176764 {ECO:0000313|RefSeq:XP_013414732.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013414732.1};
RN [1] {ECO:0000313|RefSeq:XP_013414732.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013414732.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013414732.1; XM_013559278.1.
DR AlphaFoldDB; A0A1S3JWQ1; -.
DR EnsemblMetazoa; XM_013559278.1; XP_013414732.1; LOC106176764.
DR GeneID; 106176764; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 31..112
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 142..212
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 299..474
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 256..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 55633 MW; 76007EDD84BFD7C5 CRC64;
MKPPKQDQGS MYRKPRKDLY DYQYFNREPR KVTLKKGSSG LGFNIVGGED GEGIYVSFIL
AGGPADLSGE LKRGDQLISV NGVDLRDATH EQAAAALKHA GDTVEIVAQY KPEDYNRFEA
KIHEIREQML NTSQSSLKTT QKRTLYVRAL FDYDPSKDSG LPREGLEFRY GDILHVTNAS
DDEWWQAKRI LPDGKEEGLG IIPSRRRVER KERAKVKRVD FKGKGVDSKA VGGTAADKQK
KKNFSFTKKF PFMKSKDKSG TSMEDVTVDE QTEGDNDSNR GDEPVLTYEP VIQQELKVTR
PIILLGPLKD RINDDLISEY PDKFGSCVPH TTRPRRDYEV DGRDYHFVDS REQMEKDIQD
HLFIEAGQYN EHLYGTSVAS VREVAEKGKH CILDVSGNAI KRLQVAQLYP IAIFIKPRSA
ESIMEWNKRM TEEQAKKSFE KALRLEQEFG EYFTAVVSGD TPDDIYAKVK EVIRDQSGPM
IWVPSKEKL
//
