ID A0A1S3JYW1_LINUN Unreviewed; 1638 AA.
AC A0A1S3JYW1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106177090 {ECO:0000313|RefSeq:XP_013415221.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013415221.1};
RN [1] {ECO:0000313|RefSeq:XP_013415221.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013415221.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR RefSeq; XP_013415221.1; XM_013559767.1.
DR EnsemblMetazoa; XM_013559767.1; XP_013415221.1; LOC106177090.
DR GeneID; 106177090; -.
DR KEGG; lak:106177090; -.
DR OrthoDB; 2915192at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR CDD; cd00063; FN3; 4.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00607; FTP; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013415221.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1638
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010339050"
FT TRANSMEM 962..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..519
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 626..718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 722..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1074..1331
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1249..1322
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1363..1626
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1542..1617
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 622..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1638 AA; 182348 MW; B364BD6522E85A7F CRC64;
MNGGLRHRPG SSEVLLILFI VIQVQTSLSC VEGEGYFGWL CDTQSNCFCK QAQICQKTLG
TCPPNCVDNP WGIGCSDDDV NLAQGKQASQ SSTNSNFLAS LAVDGNNSTQ GSDCALTNLQ
NDPSWLVDLG GLHVVRKIAV QKPTSGVCPF NLVFACIGNS TVTSNCRDIS RADACATAYL
EFPIDPPILG RYVRIKKVGG QILSLCEVIV KGYEYPYNLA YGKLTQQSTG ESASRAVDGN
LDTYFYHASC THTANEANPW WRTDLGAQYA VYSVTLVNRG DCCGSRLNYF DIKLRNNTIS
GSYDVCISRN TQIPEGQAVE LPCVQQFVGH VLIIQLRATN VLTLCEVLVK GYKYQACADG
AFGPQCQYLC QCQLPNEVCH TVTGQCSSGC GAGWKGHGCQ VPTACLPHWK GNGCFQEVPR
LVGPPRKVSR TGDTVTISWD AWSAATGAGT GSATRYIVEY QADGSSGSVW QRKDAGNQFS
TTVSNLNQYT DYRFRVIVVD EEGREGKSSA SATFKTCGAP LMPPQPIAIS ALLYGDRSVA
VIHYTVQGID SGITRCESLQ KIRVRYQRQG DSSTVGPNDT ANPTYSIYNL IPYSNYTLIL
SIFNNAGLEG PSRAVYATTP EGVPPKMSPP TITSQQSDSV ELSWSEPNPP GGRITRYDVR
YSTATGGQLT VVDFNETTFR GTIGNLQTNV TYAIQIRAAT NQGPGQYSDL VQAVTVEGSP
GEPNNLENSS RTDSSLTLRW NEPIKKNGRI MGYKIICSVY NSPSDTNKTY ISNSPELRQQ
VVENLRPSTR YVCGVAARTS VGYGTYTTRV LWTAPSPPVI DDESLRNSRT PRKRTRSTVT
VLLPIVSVGD KYRIVVELMS RRRKRDVNSD TRNLTSYREA MDLNLNYYIT AEVDSTRLGA
EFTVGDNQTY GGYQNTPLVE GQTYDIYFGV LSSIDGVTAQ TYSRLLSGFV PRNDDTAPSS
DAGVIGGVIA AVVLVAVIVI VVAVILMKRR RRQMSKPSSR EEIPFKNAAF KDDNLNGSTE
HITDPESPKK KHEPVTNEVL YTDAEPLYGN VEQGTDIPVA QIMHIMLWKT RELMKEEYEK
LSKDLQAACT AGRKPENNIK NRFKNILPYD HSRIVLDKLP DDPQSDYINA NYIDGYKRSN
AFIAAQGPKP NTVNDFWRMV WQVDSPLIVM VTRIVENAKA KSAEYWPNKG SVQHGEITII
SMHVEEHEDF SIRTFQITKT GESSEKSLKQ FHFTGWPDHG VPVDPTSLIT FRKKIKEYET
TVQRRGPVVV HCSAGVGRTG TFIALDYLMD QAQAEGKINI FQLVQLMRGA RPKMIQTVEQ
YYFLHYTMLE ELLCGETTIP VQEFAERYAE LKKKGSSESS TKLEEQFEVL QIMTPEIDQE
ETKTALNEEN LSKNRVRNIV PANHCRPYLE INSTQTSDYI NAVFVDGHRR FDAYIVTQMP
LPSTVVDFWR MIHDQRSATI VMLNEIIQDD EQTVAVYWPE TGTATYGHFT VEFVKSRAPS
EHLSVREYKL NNSERPKDAP QRICQFQYHG WKTSDAVPQS KSAFLGLIDE IEHWQQQSGN
TRITVHCMNG AHQSGLFCAV SRIVEKTKVE QEVDVFHTIK ATRINRPQFV DSLDQCKFCY
ECVDDYIHMF DTYANFQA
//
