ID A0A1S3JZX6_LINUN Unreviewed; 773 AA.
AC A0A1S3JZX6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=GRAM domain-containing protein 1B isoform X4 {ECO:0000313|RefSeq:XP_013415581.2};
GN Name=LOC106177376 {ECO:0000313|RefSeq:XP_013415581.2};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013415581.2};
RN [1] {ECO:0000313|RefSeq:XP_013415581.2}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013415581.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR RefSeq; XP_013415581.2; XM_013560127.2.
DR AlphaFoldDB; A0A1S3JZX6; -.
DR EnsemblMetazoa; XM_013560127.2; XP_013415581.2; LOC106177376.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 428..601
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 86755 MW; 0D110E3A3A1697D1 CRC64;
MVLGFSLKIG KTDGKTGKKT SSDEGSSISG SSSSIVPHAL SSLFTPDEER KTLVETMEEG
QPQGDLRQHN GSGTPSSTSL SATTESSSTN VTSAKSGDTV SEAEDASEHI DVALVDNHST
PTSDRSSLGN SHEKLAGKCP EDFYDINRQS ANDSGGGKSS TSRSVEKKKK GNTWYNVLSP
TYKSKSEDLK KLFKDVPNDE RLIVDYSCAL QRDILTHGRL YITQNWICFY AKIFGWETAI
TIRCKDITSM TKEKTARVIP NAIQIISNNE KYFFTSFGAR DKSYLMMFRV WQNALMDQPM
TAQEMWQWVH LSYGDELGLT SSDDDYIPPE EETPNTFISK DALDEGGEEK TDNPEDLMGK
ISPTDAVSMT TTSNEDLYDR LAPPSQNGLI NLGMVKAASF DNPDMPTDFS DDSEETEGDV
VCTCSEHRGM KIIDEVYNIS VDQMYEMLFT DSKFFRDLLD RRKTFDLVLT PWPDDADRDG
TKMRMISYTL TLNAAFGPKT SPATEKQLWL PESRPGAMYR IECECINSAI PYGDSFYVVN
QYCITRVHPH RCRLLVHSEI RYRKNVWGLV KNIIDKNCTA GIKDYFKTLV QCLREESERP
GAPFNIEPTP SKKRVRRRRR AHSRASEVPA ATSTVETNHI TVPSPVSAPG TDLDKFMKTD
VESMVKLLAV VLSVLLLFNA MLFYKMWTLE GVASNLYIGD TEEELAHLSS YPKSQEQWVK
LLRQQQHLHD AEIDKWKSIL DTSVLLLGEM KSNLEVLQQS LSARYSSKVD QPA
//
