ID A0A1S3K3I2_LINUN Unreviewed; 500 AA.
AC A0A1S3K3I2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 1 isoform X2 {ECO:0000313|RefSeq:XP_013417077.1};
GN Name=LOC106178442 {ECO:0000313|RefSeq:XP_013417077.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013417077.1};
RN [1] {ECO:0000313|RefSeq:XP_013417077.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013417077.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013417077.1; XM_013561623.1.
DR AlphaFoldDB; A0A1S3K3I2; -.
DR EnsemblMetazoa; XM_013561623.1; XP_013417077.1; LOC106178442.
DR GeneID; 106178442; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF10; POTASSIUM VOLTAGE-GATED CHANNEL KQT-LIKE SUBFAMILY MEMBER 1; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..500
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010339049"
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..229
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 356..480
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
SQ SEQUENCE 500 AA; 56578 MW; E88CC3D2B072A35F CRC64;
MMVLICLIFS VLSTIDQYSE FANETLFWME IVLVVFFGLE YVIRLWSAGC RSKYMGLVGR
LRFARKPISI IDLIVVVASV VVLSIGSNGQ VFAASAIRGI RFLQILRMLH VDRQGGTWRL
LGSVVFVHRQ ELITTLYIGF LGLIFSSYFV YLAERDQDEG ANGETDFNSY ADALWWGVIT
VTTIGYGDTV PKTWVGKIVA SCFSVFAISF FALPAGILGS GFALKVQQKQ RQKHFNRQIP
AAATLIQCLW RCYAADSRSN SVATWKIHVQ DPNRHSNSVV SKGLRRPSLI NLKRRRFSRT
KLETGSSSCN HIDRKDSEAS QVTFYIEEQS KNAKMKTDLQ LKPSPGGATD APPEYESDMH
VDVETQRVVQ LTESHKCAIR VIRRIKYFVA RRKFQQARKP YDVRDVIEQY SQGHLNMMVR
IKELQRRLDQ TIGKPGAWFD KNGTSTAADR AKLTITSRLG RVEGQVNKMD QKLDQILIML
NTLVKAKHAA VNEDSKEDSV
//
