ID A0A1S3K3W1_LINUN Unreviewed; 1261 AA.
AC A0A1S3K3W1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Helicase SKI2W isoform X2 {ECO:0000313|RefSeq:XP_013417315.1};
GN Name=LOC106178605 {ECO:0000313|RefSeq:XP_013417315.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013417315.1};
RN [1] {ECO:0000313|RefSeq:XP_013417315.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013417315.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013417315.1; XM_013561861.1.
DR AlphaFoldDB; A0A1S3K3W1; -.
DR EnsemblMetazoa; XM_013561861.1; XP_013417315.1; LOC106178605.
DR GeneID; 106178605; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_013417315.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 329..488
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 597..767
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 123..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 141491 MW; 81F41A8625BFFF96 CRC64;
MSAMAGQVVD GIDIDGLSIL SVGTCNNFDV IERRKSSDTS LPLETLPLGL PPVLPTLKAD
LEEYLSHPEK LPVYDIERTQ RFFSSKGCPD NLYLAEPTPV QTTIRVDRDM TTGQLLGYKE
EFLDDTGSSA KNSTSLSRPP GPPSEGIKGN STNYPFWPGG LEEPVFTDLA ADNLTQIDFE
TDLLSCPPGF DHGIVFECKS RTENPEGTLQ KEASQTPNLL KLSDILEADD LDFSVGEEEE
EEDKEKEGAD KDKNSADIQD LPRSESFENL VTNTDSDLGD VVTRQQEEPL ENWAIPIDLT
DPVSDFHKRI PEMACTWPFE PDIFQKQAIL RLEQGESVFV AAHTSAGKTV VAEYAIALSM
KHMTRTIYTS PIKALSNQKF RDFKQRFSNE GDVGLVTGDV QIHPEASCLI MTTEILRSML
YNGSDVVRDL EWVIFDEVHY INDPERGVVW EEVLIMLPHH VNIILLSATV PNTREFAGWV
GRTKKKKMYV ISTPKRPVPL EHFLFTGNSN KTSHELFLLQ DAKGNFLTKG YYQAIEAKKE
RTSKSSQSFG PKGARGGNPA QDKNVWLSVI DMLKKKDKLP AVAFTFSKKK IEDNASNLSS
VDLTTQSEKS EIHIFFQKSI AKLKGSDKTL PQVLHMQDIL KRGIGIHHSG ILPILKEVVE
MCFQRGLVKV LFATETFAMG VNMPARTVIF DSIRKHDGTA FRDLLPGEYI QMAGRAGRRG
LDATGTVMIL CKGDVPEMAD LHKMMLGKPT LLQSQFRLTY SMILNLLRVE QLRIEDMMKR
SFSEFHSQKS TTERKKTMAD LQEKMSTMQD LDCNVCCIDL EGYYKACREY CITKTELQKK
VLTHPAAIKA LSPGRVVIVD TELYQNTLAT VLKSTLGQNN ERMFTCLVIC EKNASSADSA
SNATKTVEGP LIKPVLVNQV LFQPEGPSGH VIVDLTAEHI GAISNVALKV NADRILEDFK
KRQIARFKND PPGQSVVTTT QELLRLAESD PHGLPSLDPV KDFGLRDIDL VEQFRRLQFL
QEELKNFACV TCSNFRKHFE EKHNYMRLKE EYAHLQFLLS DESLTLLPEY QQRVQVLRAL
KYIDNTNTVQ LKGRVACELG NQEIIITELV FENILTDLHP TEIAALLSCV VFEQKRCSEP
SLTPDLQKGK DLILKIATSI GETQRACGLL TPVDEIVESL KFGLTEVVFE WARGMPFSEI
TGLTDVQEGI IVRCIQRLDE TLKDVRNAAR IIGDPVLYRK MEEASKLIKR DIVFAASLYI
Q
//
