ID A0A1S3K4F0_LINUN Unreviewed; 1061 AA.
AC A0A1S3K4F0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN Name=LOC106178476 {ECO:0000313|RefSeq:XP_013417126.1,
GN ECO:0000313|RefSeq:XP_013417136.1};
GN Synonyms=LOC106182010 {ECO:0000313|RefSeq:XP_013422071.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013417126.1};
RN [1] {ECO:0000313|RefSeq:XP_013422071.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_013417126.1, ECO:0000313|RefSeq:XP_013417136.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013417126.1,
RC ECO:0000313|RefSeq:XP_013417136.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR RefSeq; XP_013417126.1; XM_013561672.1.
DR RefSeq; XP_013417136.1; XM_013561682.1.
DR RefSeq; XP_013422071.1; XM_013566617.1.
DR STRING; 7574.A0A1S3K4F0; -.
DR EnsemblMetazoa; g27702.t1; g27702.t1; g27702.
DR EnsemblMetazoa; XM_013561672.1; XP_013417126.1; LOC106178476.
DR EnsemblMetazoa; XM_013561682.1; XP_013417136.1; LOC106178476.
DR EnsemblMetazoa; XM_013566617.1; XP_013422071.1; LOC106182010.
DR GeneID; 106178476; -.
DR GeneID; 106182010; -.
DR KEGG; lak:106178476; -.
DR KEGG; lak:106182010; -.
DR OMA; PYPVGYM; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 1.
DR Pfam; PF00467; KOW; 3.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Elongation factor {ECO:0000313|RefSeq:XP_013417126.1,
KW ECO:0000313|RefSeq:XP_013417136.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_013417126.1,
KW ECO:0000313|RefSeq:XP_013417136.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 185..276
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 281..308
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 430..457
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 482..509
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 604..631
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 707..734
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 769..907
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 1009..1036
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..70
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 117164 MW; 62D2C95D9AE3E8B7 CRC64;
MSDSEGSVYS EDEKDRRSED EDEGSDIGRK GRRIHDSEAE EGEEEDPEPE EEPEGEDLDD
DDEEYDSEEY EDTDVRHKRK KSKHSGFILE EADVDEEGEE DEEDLEWEEG AEDIIDRKTG
FEGPSARDIE SRRRMEQMWS TQNEDEIEEY YRRKYADSSM AERFGEGEEM SDEITQQGLL
PGVKDPNLWV VKCRMGEEKA TVIALMRKFI AYQFTDEPLQ IKSVIAKEGL KGYIYVEAYK
QTHVKQAIEG VGNLRMGMWQ QQMVPIKEMT DVLKVVKETV HLKAKAWVRL KRGLYKDDLA
QVDYVEPSQN VVHLKLIPRI DYSKMRGVLR SSANEPEKRK RAKRPTQKLF DIDAIRSIGG
EVTSDGDFFI FEGNRYSRKG FLFKSFVMAA IVAEGVKPTL SELEKFEDQP EDASVELVPE
SRSVSEVSHN LAPGDNVEVC EGELIHLQGK VISIDGNKIT MMPRHEDLKD PLEFPAHELR
KYFKMGDHVK VISGRYEGDT GLIVRVEDNM VVLFSDLTMH ELKVLPKDLQ LCTDRATGVD
TMGQFQFGDL VQLDPQTVAV IVRLEKESFQ VLNMHGKVVH VKHQAVSKRR DSTRAVALDA
ENNNIQVKDI VKVIDGPHSG RQGQIKHLYR SYAFLYSRMM TDNGGIFVCR TRHLVLAGGS
KVTSTGPMLA GYMSPRLSSP AHPSGGGGGA GGPGGAGRGR GTSNRDRGLI GQTVRIIQGS
YKGYIGIVKD ATDTTARVEL HSSCKTISVD KTRIRSVSDG RPGGASSYTP RTPMYGSGGQ
TPMYGSRTPM YGSQTPLHDG SRTPHYGSQT PLHDGGGRTP AWDPTQSNTP ARANDFEYNF
DEASPSPAGV DYGTPNPATP GYSADTPSPA GGPYTPQTPG SSYSYQSSPS PGGYTPSPGG
YIPTPSPQGY GSNTPSPSGY GSTPSPMGYS PMTPGAPYTP QTPGTGMEHG AADWHTTDIE
TRIKDTHDDP NLIHQIGVIR GISAGMCSLF LPEDEKVITV SCEQLEPVVP TKGDRVKVII
GEEREACGQL LSIDGMEGVV KTDHGDLKML QMRCLCKMPP A
//
