ID A0A1S3K8E2_LINUN Unreviewed; 1155 AA.
AC A0A1S3K8E2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=VWFA and cache domain-containing protein 1 {ECO:0000313|RefSeq:XP_013418905.1};
GN Name=LOC106179725 {ECO:0000313|RefSeq:XP_013418905.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013418905.1};
RN [1] {ECO:0000313|RefSeq:XP_013418905.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013418905.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013418905.1; XM_013563451.1.
DR AlphaFoldDB; A0A1S3K8E2; -.
DR STRING; 7574.A0A1S3K8E2; -.
DR EnsemblMetazoa; XM_013563451.1; XP_013418905.1; LOC106179725.
DR GeneID; 106179725; -.
DR KEGG; lak:106179725; -.
DR InParanoid; A0A1S3K8E2; -.
DR OrthoDB; 5404639at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF66; VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1083..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 217..428
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1116..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 128833 MW; EBAE119F75DAB40B CRC64;
MGFQKRQHGV TNFPAITLVL LAVIMYRYEC SAGLIDGHSM GQILDHVVHN ALGVSEMQAA
FDQVGYNERV IDGPRTIQEL AAALQKKFAE PVNALLRVKN AIERQYVHFT DTNTMDKCCN
VTGNLVYDFR FRTKINTDES CVSTAALSPP NLKFPTALVH QTMKENLAAD PTLKWQYFGM
ETGVFMSYPS QMMDDCESYD PRYRPWYAEA ATQKTKAVVI VIDTSRSMGD THNGRTLLEI
AKEAAKSAVD TMNPNDSFAI VAFSDSATTP RFTEHQIVTE NVDTCYETKM SRATPMNAKN
LKKFIDGLSA GGATNYAAAL TKAFEFLRHS NTTAEEPSIL FLTDGILTAG GDPLQTIRDQ
NALLGNKVVI LTFGIGRSLG YEGRTVLYNM AIQSASNPAY GPIKRGRFAY VADPDHLRSA
MSSYYDYFCT IHQNPRPIFS VPYLDSLGLG LVTSLCLPVF YADTLVGVTC SDVTLSDLLT
DISTLREGEV SYAFVIDGAE RTIFHPLLPK PYNVESDQIF ININQLEKST EFKEVVQSMA
RGNHGSKSFV STRVNSRGDD FREGVHAVPV YSHYFWHPII GTNFSVCLVL GDGDRVVTLK
MPDTITPEMF KYHRLDLKPG ESQCRHFARV ATTTSSTVMF GPIAFKKLYL YLDTNETLES
VHGYESYLMG NTTDDLGLKD SVKASVAITY QAEQIWKNKQ LLSHYVVWRY IGTVDGVVRV
FPGVQLSKNF DVTQRQWFKR TATYNNKNVL TAPYLDAWGA GFVVTLSHAI YDSRYAGKNS
SSGEIVAVMA TDMTVNYLDQ IVQLYGPCKS ATYRCFIIDS AGYLVFHPYF VTVSDKPQVA
TMHMLFQEPA VGYDLVQKGI LRRESCVDLE AIKERHYWWV HLQDSAYPDG VDNMGRRPSY
ELRPITNSNV FFVIRQHPIP DTHDCLCDNY MGHPGNSSCL RDDEYPDDVC ECPCYRNALF
NYCDHVYNIS HSASSHACTP QTPDLTDMSS GEFGRVQQLK PCYDIQCANM TTQDMCYSMA
GCSWCQEASD GSQLTTPFCA TQFVCYFGRI GQTCPYDNCP GDTISTGRKD QEANQAGENG
DNIGIILGGL FGSMATVGIF AAACNILFQR MKSRRRRRYA RTRRGSPTWT SPAATSPSTS
DQSQSLPAVD EIRSP
//
