ID   A0A1S3KAB0_LINUN        Unreviewed;       606 AA.
AC   A0A1S3KAB0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Hepatocyte growth factor receptor-like {ECO:0000313|RefSeq:XP_013419565.1};
GN   Name=LOC106180194 {ECO:0000313|RefSeq:XP_013419565.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013419565.1};
RN   [1] {ECO:0000313|RefSeq:XP_013419565.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013419565.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR   RefSeq; XP_013419565.1; XM_013564111.2.
DR   AlphaFoldDB; A0A1S3KAB0; -.
DR   STRING; 7574.A0A1S3KAB0; -.
DR   EnsemblMetazoa; XM_013564111.2; XP_013419565.1; LOC106180194.
DR   GeneID; 106180194; -.
DR   KEGG; lak:106180194; -.
DR   InParanoid; A0A1S3KAB0; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd00192; PTKc; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF01833; TIG; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Receptor {ECO:0000313|RefSeq:XP_013419565.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          313..577
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         346
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   606 AA;  67764 MW;  B4125B1C6050055A CRC64;
     MRSIWILLQK CAFLVTICSI LFSGGRMLTV TGKNFDSVQQ PRMFVWNGKI TSETTYCLHI
     PEMSSTTLTC PSPRAPKGIH PTLQDTSGSL RLKRQSDSIT IAKIGFIMDG VIAVRNLTNI
     ISSLQYVVDP LFQDLTSDGS SVKYQSNASL VIRGHYLNIA ASEADVTVLI GGHKCDVTGL
     APNFLVCIPP HFDYGDKQVL IRMGNLLYQV GHLNYGDPPA DHPPVNYGWV AGLIVPIVVL
     SVIGIVTGVK VYKRCANGTT SNHNGASETE YLGLMSQATP PRVINTTEDV LMLVKDDDLK
     ATLKPVLLSR YRIRIGKLIG TGHFGCVFEA VYEDSEQSNP SKVAVKTFQG KGADIQHLDE
     FLREGALMTS FRHDHVLTIL GICFEVDGNP MIILPYMANG DLKTYIENPK NAPTGLQLLQ
     FGLDVARGME YLAENKFVHR DLAARNCMLD DQLHAKVADF GLTRDVYTKE YYSSRDKQAK
     LPVKWMAPES MERNVYTFRS DVWSYGVLLW ELFTRGKVPY PGVDGWDVLQ FLNLGRRLDK
     PDYCPQHVYQ LMLKCWSWEP EERPNFTPIV TQIEETVRVN TEVGGEPGHN EHGEGDGDYH
     VYLEVF
//