ID A0A1S3KAL6_LINUN Unreviewed; 64 AA.
AC A0A1S3KAL6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Stress-associated endoplasmic reticulum protein 2 {ECO:0000313|RefSeq:XP_013419683.1};
GN Name=LOC106180273 {ECO:0000313|RefSeq:XP_013419683.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013419683.1};
RN [1] {ECO:0000313|RefSeq:XP_013419683.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013419683.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Interacts with target proteins during their translocation
CC into the lumen of the endoplasmic reticulum. Protects unfolded target
CC proteins against degradation during ER stress. May facilitate
CC glycosylation of target proteins after termination of ER stress. May
CC modulate the use of N-glycosylation sites on target proteins.
CC {ECO:0000256|ARBA:ARBA00037157}.
CC -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC Interacts with CANX. {ECO:0000256|ARBA:ARBA00038831}.
CC -!- SIMILARITY: Belongs to the RAMP4 family.
CC {ECO:0000256|ARBA:ARBA00005500}.
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DR RefSeq; XP_013419683.1; XM_013564229.1.
DR AlphaFoldDB; A0A1S3KAL6; -.
DR STRING; 7574.A0A1S3KAL6; -.
DR EnsemblMetazoa; XM_013564229.1; XP_013419683.1; LOC106180273.
DR GeneID; 106180273; -.
DR KEGG; lak:106180273; -.
DR InParanoid; A0A1S3KAL6; -.
DR OrthoDB; 1326375at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010580; ER_stress-assoc.
DR PANTHER; PTHR15601:SF0; GEO09675P1; 1.
DR PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR Pfam; PF06624; RAMP4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 64 AA; 7176 MW; D5213021B4C1559F CRC64;
MPAKQRMRLA NDKASKNVTQ RGNVPKSLKP EEDKYPVGPW LIALFVFVVC GSAVFQIIQS
IRFG
//
