ID A0A1S3KC61_LINUN Unreviewed; 612 AA.
AC A0A1S3KC61;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ferric-chelate reductase 1 {ECO:0000313|RefSeq:XP_013420216.1, ECO:0000313|RefSeq:XP_013420217.1};
GN Name=LOC106180693 {ECO:0000313|RefSeq:XP_013420216.1,
GN ECO:0000313|RefSeq:XP_013420217.1, ECO:0000313|RefSeq:XP_013420218.1,
GN ECO:0000313|RefSeq:XP_013420219.1, ECO:0000313|RefSeq:XP_013420220.1,
GN ECO:0000313|RefSeq:XP_013420221.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013420220.1};
RN [1] {ECO:0000313|RefSeq:XP_013420216.1, ECO:0000313|RefSeq:XP_013420217.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013420216.1,
RC ECO:0000313|RefSeq:XP_013420217.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR RefSeq; XP_013420216.1; XM_013564762.1.
DR RefSeq; XP_013420217.1; XM_013564763.2.
DR RefSeq; XP_013420218.1; XM_013564764.1.
DR RefSeq; XP_013420219.1; XM_013564765.1.
DR RefSeq; XP_013420220.1; XM_013564766.1.
DR RefSeq; XP_013420221.1; XM_013564767.2.
DR STRING; 7574.A0A1S3KC61; -.
DR EnsemblMetazoa; g641.t1; g641.t1; g641.
DR EnsemblMetazoa; XM_013564762.1; XP_013420216.1; LOC106180693.
DR EnsemblMetazoa; XM_013564763.2; XP_013420217.1; LOC106180693.
DR EnsemblMetazoa; XM_013564764.1; XP_013420218.1; LOC106180693.
DR EnsemblMetazoa; XM_013564765.1; XP_013420219.1; LOC106180693.
DR EnsemblMetazoa; XM_013564766.1; XP_013420220.1; LOC106180693.
DR EnsemblMetazoa; XM_013564767.2; XP_013420221.1; LOC106180693.
DR GeneID; 106180693; -.
DR KEGG; lak:106180693; -.
DR OMA; YTTHYIL; -.
DR OrthoDB; 2908958at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF36; DEFENSE PROTEIN L(2)34FC; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..612
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014546022"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..186
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 345..545
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 612 AA; 69346 MW; 7B0DA9422AB20CB7 CRC64;
MKTGRCAGRI LTIFFGLFLQ GFSYPNGGIL KTCVNLLPKH HGTNQQTGKA PYTLSVAKDT
YKPGEDIAIE LKSQKIPFRG FQIMVHRREG DTEELIGNFT EFSTDSKPFK WYSENINCLT
HSDNEDKTKV QFKWKAPGVS EGDLIVRAAF VKDFEHFWAN ETHVLRAEVP VVVNETFPWR
VSMDFKPMRV REECGVTKGC VKWPRLCQGE DCDVLVMYKT EGDHIDFEMF GKAEAYLSLA
FSDDKKMGKD ETITCMYKES VIQIQHGYNP MYFNERIRNT VLSNVEMMRD GERMYCRFRR
PLSFTPDLWL SLANKYPPTP IKAITFDLSK PWILFLGWGH LYTGTDVVGH HKELPLITSS
PVDFQSTAVH YGQTLSVEVQ AHGTLMTVAW VALAGFAMVV ARHYRNAFGN NCCGIKLWFQ
IHRLIMILVA GCTAAGIVLI FVYVGDWREV ATLHAGFGLA VMGIVLLQMI MAFCRPDPDA
SRRRVFNWAH RIFGKLSHVV AVVALFLGVN LSLLPEKFRF NQTVVLGVWV ITQILWEVIL
EIMKCRREAS DKREITISMD PIGNGDHTKS SLDSVENPRK KQGSAILACA LALYGITLLV
FVAAILALIY MF
//
