ID A0A1S3KEH6_LINUN Unreviewed; 542 AA.
AC A0A1S3KEH6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Digestive cysteine proteinase 1-like {ECO:0000313|RefSeq:XP_013420646.1};
GN Name=LOC106180980 {ECO:0000313|RefSeq:XP_013420646.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013420646.1};
RN [1] {ECO:0000313|RefSeq:XP_013420646.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013420646.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_013420646.1; XM_013565192.1.
DR AlphaFoldDB; A0A1S3KEH6; -.
DR STRING; 7574.A0A1S3KEH6; -.
DR EnsemblMetazoa; g7491.t1; g7491.t1; g7491.
DR EnsemblMetazoa; XM_013565192.1; XP_013420646.1; LOC106180980.
DR GeneID; 106180980; -.
DR KEGG; lak:106180980; -.
DR InParanoid; A0A1S3KEH6; -.
DR OMA; EYDIGAM; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF975; 26-29KD-PROTEINASE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..542
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018783886"
FT DOMAIN 240..296
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 324..541
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 542 AA; 61970 MW; 57C8A87595983450 CRC64;
MAWRIAYLVF AGFLGTCLGA APTKPSIAKA YQVGGMLQLP YAEIKEPFYA YYDGHNNRTR
IDYYSGMSKM YQRGDLKKSY SVVFTSYSDD KLNQLTCFES GGMPQLQSVF PDLTNFTLYA
KGQPHPTGAN ITVDAWRFVM TVGKKKNTYT FYVDSKKQIP VRYEMFGYDT LMGSHYDKYY
IDYHGYLEYT NTSLNVSVFQ PTVKNCSVGY TQTKNSEKRI LMNPMREYVH HDDLHIHEMF
EDFKKTYQRN FMTIKEHETR KFNFRHNVRF IHSKNRAGLS YKVAVNHLAD RSPWEMKKMR
GRLYKPGYNG GLPFNKKMYE SIKLPSQVDW RNYGAVTPVK DQAVCGSCWS FGTTGTLEGT
YFLMTGKLLK LSQQELIDCS WGEGNMGCDG GDDFLAYQWI RKHGGLTTEE IYGSYMAVDG
KCHWKTNGTR VQIKVWYNVT SGDSDALKMA LAKHGPISVA IDASHKSFSF YSNGVYYEPK
CGNAPEQLDH AVLAVGYGTM NGKAYWLVKN SWSTYWGNDG YVLMAQKDNN CGVETDPTFV
TM
//
