ID A0A1S3KFS2_LINUN Unreviewed; 1141 AA.
AC A0A1S3KFS2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulin receptor substrate 1-B isoform X4 {ECO:0000313|RefSeq:XP_013421309.1};
GN Name=LOC106181472 {ECO:0000313|RefSeq:XP_013421309.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013421309.1};
RN [1] {ECO:0000313|RefSeq:XP_013421309.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013421309.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013421309.1; XM_013565855.2.
DR AlphaFoldDB; A0A1S3KFS2; -.
DR EnsemblMetazoa; XM_013565855.2; XP_013421309.1; LOC106181472.
DR GeneID; 106181472; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF8; INSULIN RECEPTOR SUBSTRATE 3; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_013421309.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 60..164
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 158..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..921
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 122208 MW; CCBEC78CD01F2DF1 CRC64;
MLFSPLAVLC KSCHKPKQCI TPISAGHKSH LMPNQQKSKT KLWSPLAVIK GGSTSALPNR
EHVWQVTVKP RGLGSSKNLV GTYRLCLTSS SLSLVKLNHE KPEITFQLAA IRRCGHSDCF
FFMEVGRSSA TGAGELWMQV EDTIIAQNMH EAILSSMKSM SSGQEAGQQI RPRTSSTLSD
KTRPASAVHR SRDDHGPHRS RTSSEGHKRS RHSPTVMRKD RNLLTTHAGS HSSVSSGHSP
MTGSPLSATI LNESLNPSGF RGRSDSTDSR GTSSSISDEC DGHSGMRSTT PDQSQTDSQS
DYLSMTPNTM MGASPVGSLD SNKNLEYMEM DLTSKFSSPH TPHHHHHHHH HHHPPEGLTL
HDINASSSKG APSESSYMSM TPTSSLSSSP RFGTPSILSD DSSYLDMAPL GQGLPPLQEK
ATPDGYMDMA PTHTSGSRSV LRPAKSFLHE APEFPQRAYS VGSRPGKSLS TQIQQPYMEM
VASQGALNNS KSSSAPHLEN ENINANVKST KGHTRYASPS PSGAREGGGG MQPMKAFPPQ
QTDLFMEMDF ARPRTASDSF NYQHCRPRTS SWSKAMRPRS ASHSQGSKIN GRKLLSRDAA
PSQELIKQIS QDSLRRSYDS ISKLGSTPEQ HEAYMEMSPQ SSSKRSPATK PVSMRVTPVI
KTTLIAPDYM MMNPVIKESK TEPDESESDN NDSVSDSKLN GSRSSSSSSS ITEQRRQSSP
DVIRQSANQS PGASKVQAPF DPVTYVNLDY SKKPVKEPAV PPGDDSYLML SPGTEDTSQA
AIDSGSLSPQ RVVSHIRVSS SPASTTAMQE AAGNHGSAAA STSVVKKPPL PDTPKILSSP
GESGTVKAPK PTTPAPFPTS PPVPTSPAPS HPLSTPPPFP MSPPFSVPSP ARISPTTPPQ
PTTPTAPVLA KPTPPLPISP SSKGESSPQS PSAQTQDYAN IDVGVTRVVK PVPTFGSVQS
VTSDGSTSQV EKPALPSKNK VGRSKQQRAE KSKSMGDCQE RPESVNVNTA NSKKCPPPPV
SASASKVSSK PPSLPPLPPL GQRHSMSDFG ANNNGMGESG PGKVPPSAQD EPQLNYASLD
LGSSEDIELT QAPKSPRIIT SRHNSGEDGE KKPTYAEIDF EKSESFKQAR QQSGRKPPFD
L
//
