ID A0A1S3KGL3_LINUN Unreviewed; 965 AA.
AC A0A1S3KGL3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Adhesion G protein-coupled receptor L2-like {ECO:0000313|RefSeq:XP_013421594.1};
GN Name=LOC106181684 {ECO:0000313|RefSeq:XP_013421594.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013421594.1};
RN [1] {ECO:0000313|RefSeq:XP_013421594.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013421594.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR RefSeq; XP_013421594.1; XM_013566140.1.
DR AlphaFoldDB; A0A1S3KGL3; -.
DR EnsemblMetazoa; XM_013566140.1; XP_013421594.1; LOC106181684.
DR GeneID; 106181684; -.
DR KEGG; lak:106181684; -.
DR InParanoid; A0A1S3KGL3; -.
DR OrthoDB; 2945484at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF473; FI21270P1-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_013421594.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 706..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..354
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 702..943
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 965 AA; 109249 MW; 1CF34EB3BC00651E CRC64;
MYKARKIESM ETLHGADCIG RYYTWPTCQD NPDGYGCLCG PGFYWNTRLC ISTSVNSRFE
LNGDHNDRHT LKNGYAKLVG KTFPDLIHLT ITMWVRVPNS TTDGTLLSYS TRNYSNLIQI
TAGRTVKFSL HGETRDTGLM LQHGFWVHLA FTWSAIDGSW FVYENGAKIS LPYMDTVGKR
KPILRGGDMI LGQSYLGQNG HVQYDSPFIG DLSHVNIWKQ VLSEDEIRKV YSDCTFTHCG
TAVQWTEFRF GTHGNIHLRW PSEIVDQTCF TDVWAAETCD DHCSYVIGAQ CNEEIVENIR
WSRTPAGHNV SVPCPGRVDD SGNATAFAYR YCNITNDNKG VWGEPQIDEC LSQKQLSLKT
EIAELLGLPS FDEDRMFHLG NALLNHTTYT SYTNPIDIAA EIDSLNLLIK AQGINLRDVV
WKSDMLHSFA RTLELYPSFE KTIEFTKLIC GIVNDLVATK NDAGWRGVQP PGAEGEVLIA
SVEKFTSLVA KTLIYHVKHK HIGSEEATVS ALYDNIAVKV RVFLRDRFMG FAFPDHTDTF
ALEMSDDIGT LALTKEAITE LNETIPNLFA IASVRFSNMA RLLPNHNITI KSKRDNVNSV
VYSLNVYFEN DRNLSSTNLS SPVKLYLPYT DDFNISNPDC VMLRHREGTR QWRWSSGRGD
CYVIRNDSSY ATCGCYRLGT YAVTTDMFNV DWDRGEHPPH LMTTPSYVGC AMSTVLCLGS
AVMLIYLRTS SPSAAIHKNF GFSISLCQLI FMVGVTQTSN KTVCHVFAVL FHYFFLTTFS
WMMNEAFNLY IKITYAAHSH GPVSESGSIW RYYILGWVVP GALVGALVGS HGDSYYAADM
CWIRWDLVWF FIGPVIAIQA VSILVLIFTA KEYHESSYTK NEKANKILVN HTKAVWTQVV
LLTVVWTFAF LSLKMRGPIL KYLYALLNFL QGSFFLVFYF LLNEEMPDKK IKSLSRSRFA
KIQRE
//
