ID A0A1S3KIP3_SALSA Unreviewed; 898 AA.
AC A0A1S3KIP3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Circadian locomoter output cycles protein kaput {ECO:0000256|ARBA:ARBA00040572};
GN Name=LOC106560272 {ECO:0000313|RefSeq:XP_013978470.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013978470.1};
RN [1] {ECO:0000313|RefSeq:XP_013978470.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013978470.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR RefSeq; XP_013978470.1; XM_014122995.1.
DR AlphaFoldDB; A0A1S3KIP3; -.
DR GeneID; 106560272; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd19734; bHLH-PAS_CLOCK; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF2; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 26..76
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 287..334
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 547..588
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 101036 MW; 3E8839B239AA432F CRC64;
MTSSIGGDDA SSIFDGLMEE DEKDKAKRVS RNKSEKKRRD QFNVLIKELG TMLPGNTRKM
DKSTILQKSI DFLRKHKEIA AQSESSEIRQ DWKPPFLSNE EFTQLMLEDY SSSRLSAMAL
DGFFLAIMTD GNIIYVSESV TSLLEHLPSD LVDQNLLNFL PLVEHSDVYK ALSSHILEGE
TLTPEYLKTK NQLEFCCHML RGTIDPKEPP VYEYVKFIGN FKSLNNVPNS TRNGLEGVIQ
RSLRPAFEDR VCFIATVRLA KPQFIKEMCT VEEPNEEFTS RHSLEWKFLF LDHRAPPIIG
YLPFEVLGTS GYDYYHVDDL ETLAKCHEHL MQYGKGKSCY YRFLTKGQQW IWLQTHYYIT
YHQWNSRPEF IVCTHTVVSY AEVRAEQRRE LGIVEESPPE ISAVDKQSQD SGSESQHQLN
TSSLKEALEG FDRSRTPSAS SHSSRKSSSH TAISNPASPK LKTDRGTPGC QSVSAIEMTS
QRRSSISSQQ SMSSQHTQNT GQNMAPSMVP QQQPQQQQQQ LQQQQPPPQQ QQQQLQIQPS
VQFSTQLDAM QHLKDQLEQR TRMIEANIQR QQLELRQIQE ELNKVQGHGL QMFLQPGTSG
LSLGSVQLAH GTTMQPGGAL TMQGQVVSAG SLQGSTPQQH TVQQQPQQQS QPQQQNLLRD
TSSVLSQSSV RSTHSLPPQQ SALPASLYNT MMISQPNQAN VVQIATSLAQ NSSNNTAAMA
NFAQDRSGQI RFPAGSQLLT KLVTGPMACG AVMVPTTMFM GQVVTAFAPQ QGQTQTISIA
QQQPQQQEQQ AQSQAEATQQ GLAQQQTQFL QGPRLLHGNQ STQLILQTAF PLQQQGAFAS
TQHQQQQQLQ QQHQQQQQQL QQQQQQQQQQ LQQQQQQEQQ LASHRADSMS GRSSTQPQ
//
