ID A0A1S3KIX6_SALSA Unreviewed; 847 AA.
AC A0A1S3KIX6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Volume-regulated anion channel subunit LRRC8D-like {ECO:0000313|RefSeq:XP_013978537.1};
GN Name=LOC106560304 {ECO:0000313|RefSeq:XP_013978537.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013978537.1};
RN [1] {ECO:0000313|RefSeq:XP_013978537.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013978537.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_013978537.1; XM_014123062.1.
DR AlphaFoldDB; A0A1S3KIX6; -.
DR STRING; 8030.ENSSSAP00000027934; -.
DR PaxDb; 8030-ENSSSAP00000027934; -.
DR Ensembl; ENSSSAT00000049974; ENSSSAP00000027934; ENSSSAG00000034892.
DR GeneID; 106560304; -.
DR KEGG; sasa:106560304; -.
DR OMA; DFDHVCE; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR Bgee; ENSSSAG00000034892; Expressed in camera-type eye and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..373
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 65..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 96918 MW; DCB631AA5676B9C2 CRC64;
MMFTLTEVAA LNDIQPTYRI LKPWWDVFMD YLGVVMLMLA IFSGTMQLTK DQVVCLPILE
PASEDPSGFT TPQPAEGSGS GTGNGGSRGT LDAAPLVTKD LPDSVVHQIH FTHSGGVGQQ
PLPTGVRTNL DFQQYVFVNQ MCYHVALPWY SKYFPYLALI HTIVLMVSSN FWFKYPKTCS
KIEHFVGILG KCFESPWTTK ALSETACEDS EENKQRLTGA PFLPKHISTS SEEGSPNQST
PMLAKSGVKF TADKPVIEVP CMTILDNKDG EQAKALFEKV RKFRTHVEDS DLIYKLYVAQ
TVIKTVKFIL ILCYTMTFVA AIDFDHVCEP DIKHLTGYTK FQCTHNMAFM LRKLLVSYIS
LVCIYGLICI YTLFWLFRRP LKEYSFEKVR EESSFSDIPD VKNDFAFLLH MVDQYDQLYS
KRFGVFLSEV SENKLREISL NHEWTFEKLR QHVTRNAQDK LELHLFMLSG LPDAVFDLTD
LEILKLELIP EARITAKISQ MINIQELHFY HCPAKVEQTA FSFLRDHLRC LHVKFTDVAE
IPTWVYLLKS LRELYLVGNL NSENNKMIGL ESLRDLRHLK ILHLKSNLTK VPTNITDLSP
HLIKLVVHND GTKLLVLNSL KKMMNLAELE LHNCELERIP HAIFSLTNLQ ELDLKSNNIR
TIEEVISFQH LKRLICLKLW HNKIITIPLS ISHVKNLESL YLSHNKLESL PIPLFNLLKL
RYLDISHNSI VVIPLEIGFM QNLQHFAITG NKVEVVPKQL FKCTKLRTLC LGHNCIAVLP
ERISNLVQLT NLELKGNCLD RLPPQLGQCH HLRRNCLVVE DHLFDSLPLE IKESINQEAN
VPFANGV
//
