ID A0A1S3KIY1_SALSA Unreviewed; 790 AA.
AC A0A1S3KIY1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Volume-regulated anion channel subunit LRRC8C-like isoform X1 {ECO:0000313|RefSeq:XP_013978541.1, ECO:0000313|RefSeq:XP_013978542.1};
GN Name=LOC106560306 {ECO:0000313|RefSeq:XP_013978541.1,
GN ECO:0000313|RefSeq:XP_013978542.1, ECO:0000313|RefSeq:XP_013978543.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013978542.1};
RN [1] {ECO:0000313|RefSeq:XP_013978541.1, ECO:0000313|RefSeq:XP_013978542.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013978541.1,
RC ECO:0000313|RefSeq:XP_013978542.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_013978541.1; XM_014123066.1.
DR RefSeq; XP_013978542.1; XM_014123067.1.
DR RefSeq; XP_013978543.1; XM_014123068.1.
DR GeneID; 106560306; -.
DR KEGG; sasa:106560306; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR Bgee; ENSSSAG00000030668; Expressed in semen and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF22; VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..324
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 790 AA; 92182 MW; 9A89DF4371B21C9E CRC64;
MIPVTEFRQF SEQQPQFRVL KPWWDVFTDY LSVVMLMIGV FGCTLQVRQD KIICLPQKMT
MYNQTILLPN KTAVQPDVPE MMGRKTNLDF QQYSFINQMC YEKALHWYAK YFPYLVLIHT
LIFMVCSNFW FKFPGSSSKI EHFISILGKC FDSPWTTRAL SEVSGENPEE KVLLDTKKSR
AILNVSIEGN LDNLEKTQSL KSVPEKIVVD KPTASALDKK EGEQAKALFE KVKKFRLHVE
EGDILYVMYV RQTVLKVFKF LLIIAYNSAL VSEVQITVKC SVDIQDMTGY KHFSCNHTMA
HLFSKLSYCY LCFVAVYGFT CLYTSYWLFY RSLKEYSFEY VRQETGIDDI PDVKNDFAFM
LHMIDQYDPL YSKRFAVFLS EVSENKLKQL NLNHEWTPEK LRQRLLTNHN DRLELQLFML
SGLPDTIFEV TELQSLKLEI INNVTIPASI TQLENLQELS LYQCSLKIHT TATSFLKEKL
KVLRVKFDDS RELPHWLYHL RNLEELYLIG SLSPDASKNV GLESLRELKH LKTLSIKSNF
TKIPQSIVDV SSHLQRLYIY NDCTKLVMLN NLKKMVNLTE LELVHCDLER IPHAIFSLTN
LQELDLKENN LHSIEEIVSC QHLRKLTCLK LWHNSICYIP EHIKKLGSLE RLYFSHNKIG
ILSPHLFLCN KLRYLDLSNN DIRFIPPEIG VLQSLQYFSV TCNKIENLPD ELFFCKKLKT
LKLGKNMLSL LSPKISYLVL LTHLELKGNH FELLPPELRF CRALKRGGLV VEDVLFETLP
SDIRDKMKAE
//