ID A0A1S3KN43_SALSA Unreviewed; 2127 AA.
AC A0A1S3KN43;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106561044 {ECO:0000313|RefSeq:XP_013980088.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013980088.1};
RN [1] {ECO:0000313|RefSeq:XP_013980088.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013980088.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_013980088.1; XM_014124613.1.
DR STRING; 8030.ENSSSAP00000103066; -.
DR PaxDb; 8030-ENSSSAP00000103066; -.
DR GeneID; 106561044; -.
DR KEGG; sasa:106561044; -.
DR OrthoDB; 4039914at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 12.
DR CDD; cd14615; R-PTPc-J; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 18.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR PROSITE; PS50853; FN3; 14.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013980088.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..2127
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010226416"
FT TRANSMEM 1764..1791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..191
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 192..278
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 279..365
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 366..450
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 451..533
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 534..620
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 621..712
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 713..800
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 801..889
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1058..1149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1236..1326
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1327..1417
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1418..1502
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1507..1605
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1832..2088
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2006..2079
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2127 AA; 231101 MW; 825F062327C4C1C5 CRC64;
MFGIMSRMSC FGVLLMTSVV LYLFLKGSQA QCAPCTNFKA STTATEINIQ VHANCTVSTG
GISVFCNSTM ATLSGLAPGS THSVHVLCND IQKVNCCNNF TTKPETITIL TVTKITTSSV
SLSWTKPEGS SFYKVEWTDG SINDSQNTTG TSVNVTGLTA GVQYNFTVTA VAGDNKSEGQ
NKTVLKYTKP AIIRKLTVSE IRTSSVSLSW TEPEGNSSFY IVEWTDGSDI GSKNTTRTST
TITGLPAGVG YTFRVTAVAG DNTTVGEGTE ATTFTKPAII RNPTVSEITT SSMSLSWTEP
EGNSSFYRVE WTDGSKTMNR TTHETAFNIN ELTAGVWYTF RVTAVAGDNM TEGVAYVTNQ
TTRPAVIATP TVIQTTTSLS LSWTKPTGEA SSYRVEFHNG GTVKDQLTST TSAIIESLTQ
GTQYTLQVIA IAQDKLEGDP RTVYVYTKPG VVGNLNVIGT TTSSVYLSWT QPKGNSSFYR
VEGTGVSMNT TETSTTITGL TAGVQYSFTV TVVAGDKTTV GEGNTTTTFT NPKQPVNIVA
KGPGTSQLNV TWTLPGGSVD QYNVNISNAA LSYTSSQTTQ TTTASFTGLQ SGRVYEVTVT
AVAGHFSNRS ATGQLATVPN PPGPLNITER TTSSLCVQWK TPGLMTGAPD ISYNISYLST
GTGASSQSTS SLRHNLLSLS SGTFYTITVI TVGPQNLGSA PVNTSGYTLP NPVVSLTVSP
LSTSSVKLQW TDPVDVKSYY SYRVQYSNAT GPVGEKTVIT SSAVVPGLEP GTGYTFTVTT
VAAAGTNGIL EQTFSYTKPK AVSNLMVEDL NTTAIKLSWS EQDDHKPTYS YLVTVSKRGS
MVANVSTTVK SYTFTHLQPG DSYTFSVVTV VQGVKSDAAE TTSYTKPGVV TNIATTGTTN
TMNVTWDAPV GQVDSYTVTI YNNNVMENSH TISNDSLELV FQNLKPGKVY VVRVVTNSGP
LTEASLNVTN ATYPNPPGTQ MVEDQTTGSI NISWARPLDM DLGQYRFSVF HLGQHNLTEH
NWILLENLQS GTLYNITVVT VGPLDYQSTA VTTANYTRPH SVSGLTEAGI TPTNVTLVWD
QPKNKAGFSF KVEVTYPNGS LFISVTVNNT KIIVTGLQSG SNYTFTVTTL TEDGTMATPV
KVFYYTRPYP ISGLLAPTVN TTGVRLTWTK PPQYKSGYTY RIQTEGCVST PTNHTVTGEV
AVIPELTPGT NCTFRVSVKA QDGIEGGTVS IFQYTEPESV QPSISNNGST NTMVVSWAAP
PGNVGQYVVH LNSTDQVFTP VWLNSNQQSH TFIYLSAGRE YTAVVTTISG PFNETSGPVT
TATQPNPPGP IVILEKTTSS ITVEWVEAPQ MANTTFSYLV KYLSTQQDNK TVTTTNTSQT
LPSLYSGTPY NMSVVTVGVL GFHSEEVWSS LVTTRPESVQ SLSAVTAEVN LTLTWSKPVG
HKPGYSFRVT WTNSTGLIIS NRTTAMENLP INGLVPGSLY NFTVTTQTDD GTEGAPVSTS
SCTNASPVSN LKCASPNDPN AKLNLSWTKP KGLHQGFQIT AKETIQLPQG QVHNKTIGDC
NPACGYTVPD LKHYTDYTLT VTTLGCGKTS TVQSLTCKTG ITVPPIPADV ESLVSVTAKD
HNSFSVQLTP SLLDSTNGPI KHYGVLVTSD INNVDQSNSS QYLVKTYQDW EAGSTTAYLA
TVKDNTNNSR RRKRAGNIDI YIGDKTSWNG YTNGQLKAKR EYSYAIVLFT EMVVEQNGLL
NVGSSLITIT LFNSNSFYLP QDPVVTSVAV GVTLGVFVIL FIITAGFIIY WRRQNKDSSD
IQIHSMSRTV VVRVEDYEAY YKKQRADSNC GFAEEFEDLK LVGTAQAKTS ALAMENKSKN
RYNNVLPYDS SRVKLSIHGS PFDDYINSNY IPGYNSRKEF IAAQGPLPGT VNEFWRMIWE
KNVQTLVMLT RCNEQGRVKC EEYYPSETKH FENITVTTTS EIPLEDWTIR DFDVKNVKTV
ETRSVRHFHF TAWPDHGVPE TTELLINFRH LVREHMDQYS RHSPTVVHCS AGVGRTGTFI
AIDRLIFQIE RESMVDVYGT IHDLRMHRPL MVQTEEQYVF LNQCAMDIIR SRTGTNVDLI
YQNTAALTIY ENVEPRKDTS KNGYHNA
//
