ID A0A1S3KP04_SALSA Unreviewed; 1259 AA.
AC A0A1S3KP04;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|RefSeq:XP_013980320.1};
GN Name=LOC106561174 {ECO:0000313|RefSeq:XP_013980320.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013980320.1};
RN [1] {ECO:0000313|RefSeq:XP_013980320.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013980320.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013980320.1; XM_014124845.1.
DR AlphaFoldDB; A0A1S3KP04; -.
DR STRING; 8030.ENSSSAP00000111753; -.
DR PaxDb; 8030-ENSSSAP00000111753; -.
DR Ensembl; ENSSSAT00000146729; ENSSSAP00000111753; ENSSSAG00000078251.
DR GeneID; 106561174; -.
DR KEGG; sasa:106561174; -.
DR CTD; 5923; -.
DR OMA; SCNTNGY; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR Bgee; ENSSSAG00000078251; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 241..427
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 468..587
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 634..749
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1024..1256
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 182..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 143556 MW; C4192EBADC214FB0 CRC64;
MQKGIRLNDG HVTYLGLLAK KDGTRRGCLS KRSSDNTKWH TKWFALLQNM LFYFESESSS
RPAGLYLLEG CVCDRAPSPK PSQSSKECLE KQYYFTVNFT HENQKALELR TEDIKDGDEW
VAAITHASYR NLATEHETLM QKYLHLIQIV ETEKTVAKQL RQQIEDGEIE IERLKSEISG
LHKDNGKIQS SPTAEPSEDD DSELKKIKKV QSFLRGWMCR RKWKTIIQDY IRSPHAESMR
KRNQVVFSML DSEAEYVQQL HILVNNFLRP LRMAASSKKP PITHDDVSSI FLNSETIMFL
HQIFYQGLKA RIASWPTLVL ADLFDILLPM LNIYQEFVRN HQYSLQILAH CKQNRDFDKL
LKQYEAKPDC EERTLETFLT YPMFQIPRYI LTLHELLAHT PHEHVERTSL DYAKSKLEEL
SRIMHDEVSE TENIRKNLAI ERMIVEGCEI LLDTSQTFVR QGSLIQVPMS EKGKITRGRL
GSLTLKKEGE RQCFLFSKHV IICTRGSGGK LHLTKNGVVS LIDCTLLEDP EGTDDESKPD
KGVQDMEHLD FKIVVEPKEG QSFTVILVAS SRQEKSAWTS DISQCIDNIR CNGLMMNAFE
ENSKVTVPQM IKSDASLYCD DVDIRFSKMM NSCKVLQIRY ASVERLLERL TDLRFLSIDF
LNTFLHSYRV FTSADVVLDK LITIYKKPIS AIPARSLELF FASSQNNKLL YGEPPKSPRA
SRKFSSPPPL AITKTSSPNR RRKLSLNIPI ITGGKALDLA ALSCSSNGYA SMYSSMSPFS
KTTLDINKLY VTSPITSKIP DEGEGKTDKA EETIVSKQDI SVPEESDIDQ NQSDDADPET
SPIKSPTTPK NMKCKNSSEF SLFSYNNGTV MSSCRPEMDN NNRSALSAAS AFAIATAGAN
EGTPTKEKYR RMSLASTGFP TDQRNGDKEF VIRRAATNRV LNVLRHWVSK HSQDFESNTE
LKLKVIAFLE EVMHDPELLT QERKAAANII RTLTQEDPGD NQISLEEVIQ LASVGKAEAF
ESHSALEIAE QLTLLDHLVF KVIPYEEFFG QGWMKNDKNE RTPYIMKTTK HFNDISNLIA
TEILRCDDVT TRVAVMEKWV AVADICRCLH NYNAVLEITS SLNRSSVFRL KKTWLKVSKQ
TKTVIDKLQK LVSSEGRFKN LREALKNCDP PCVPYLGMYL TDLAFIEEGT PNYTEDKLVN
FSKMRMISHI IREIRQFQQT AYKIDHQPMA AQYLLDNSSV LDEESLYEAS LRIEPKVNN
//
