ID A0A1S3KRC2_SALSA Unreviewed; 2214 AA.
AC A0A1S3KRC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Centrosomal protein of 290 kDa isoform X3 {ECO:0000313|RefSeq:XP_013981145.1};
GN Name=cep290 {ECO:0000313|RefSeq:XP_013981145.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013981145.1};
RN [1] {ECO:0000313|RefSeq:XP_013981145.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013981145.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
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DR RefSeq; XP_013981145.1; XM_014125670.1.
DR OrthoDB; 3030377at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR InterPro; IPR032321; Cep209_CC5.
DR InterPro; IPR026201; Cep290.
DR PANTHER; PTHR18879; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR PANTHER; PTHR18879:SF20; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR Pfam; PF16574; CEP209_CC5; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 1282..1409
FT /note="Centrosomal protein of 290kDa coiled-coil region"
FT /evidence="ECO:0000259|Pfam:PF16574"
FT REGION 176..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1879..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2084..2181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 401..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 474..564
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 691..746
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 784..878
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 955..1020
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1073..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1131..1179
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1529..1581
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1631..1748
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1778..1861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1915..2035
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 176..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2096..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2113..2147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2157..2176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2214 AA; 257212 MW; B887BC42736F568F CRC64;
MPPHLDWRMV MDADPEQLQE SGDAEIINHM FLQVKRWERE LKDGSTEKIV QLLRVVQGLL
KLKKEEVTMA FELIDNAGTE QARSENEWKA KELKWEQELE MAKKSGIGGG PDTRFLRDEM
RTLEAQLDRR EKDIQQLEKE TSKEKKINEE LMIRAEEAED ESRKLKRENE QLQQDVDFYR
RELDQKEPVQ SREESTETQR RLNSANRQLY QCMEDVQRAE EEVAHLKTQN DQMQKSLEES
VKEMETMTDE YNKMKIVVQQ TDSIMDQLRK ERDHAKLQVR ELTEQIQSRA EEDDPVMAAV
NAKVDEWKRV LAGKDEEIME YQQMIRELRD KLRSTQMDTD KSNIIALQQV IYELCGAVLE
RDNQIKMLTE QVEQYTGEME RNALLIEELK KPLKKDRGLP SAIQQRKLDE LTAKLQATET
RAQDAERVAE LAETDARNKD KELSDALNHM RLYESGTDGL QVAIAEIKEC KNQMRVRDRE
AEAMTREINQ LEMRINNLLD ENEDLRERLS LDPKEEVDLT EFRRTKSLKQ RQFQAENQVL
TKEIERLEEE RLELKKQIRR MVKDKGITVT SSLQEDDAKP TRSIKLTPTP TFSSADEEEM
KRKYEHLRRE LNHKERDLEH QRTQSSQFKS KLEDLFKENK QLEQGMKEIL QVIQDAQQKT
PSSQAAVSIP SLEKLVRAIE MKNSDGKFDT SHHLKAQVDQ LTGRNDEIRQ EMRAAREEAA
SAMSQLVKAK EKVTHLEADM EALRKSKGGG VIFRTLNLPD DMALSSTEVI SSLNEYAVRL
LREIKNKEES SQQLVAALEE YKGKFAVIRH QQGLLYKEHQ SEKEVWQKEK ETFTEMKNKL
EEQKLVDTVK IKEFNHWLEA LQKDPEELRR QVAEAARRMT VLRVNEKSLT HRYTTLLEQE
QHLRKDNNKL RDDFSTMQAS VTQRIGYLTR YKDMTAYKLA ALQKALDDSV PSSELERANK
QYTELTVKYR DMLQKDNHLV QRTTNLEHLE GENMSLREHI TALNKELEIT KEKLHTLEQA
WEHINTLGGE SSMDKAAKAV ANSEIISTSR RITTLEMKEL NERQRAEHAH KMYEHLRNSL
RLVEERNVEL ETKFAELTKL YLGAQRMERE LRDELADSVS KDASNADRAR ITQLEKAEAE
LKVEASMLRE VSDVAKMQVS ALEARQQSRE KEVEALRRQV LDYQSQSDER ALIAKLHQHI
VALQLSESAA VGKLEATATR IQQLEAYMLR AEQKLDASEK SLYHARQEGR NRARHLQQSI
QSLRRQFAGA LPLAQQEKFS QTMMRLQDDR GTAQEEKRRA EEERRRMEGK AQELELRLKG
LEELIATLKD VKGAQKVNEW HKKIEEVRLQ ELRRGRELGV QREEISYLRS LVAEQERTIR
TLEEDSVQQH TVQEERQMSW DQREVELERQ LDLYEKQQNL IIGSAQKFEE ATGALPDTSL
PLAHQLDFAL RKIKEHVRTI LETQATCKTL DEKLKEKESA LWKAEQNILS RDRVINELRL
RLPAAADRER LLADLAKHQE DQRESQPALK VAHQTINNLQ GRLDQKEEVL KKYQNLLART
RQEQEDITRR HEEEMRTLHQ KVDLQTDTSL DRFKQTALEL MKKPTITVPT TKHLVRLAEM
EQTVVEQDRS LSSMTDRLKG LIAELDRQRN LTAMQAKEHA SERVKLEERH AAQAKALSGE
AEEQRAQLGQ MEKELHYLRT ELEAQKQANI RSPSNTMKNL VERLKAQLNQ KEKQLKALSK
ALLALRAEMT SHAEQQIIAN ASHREDSLNV QLLVDKHTKD LKARVQELNE ELQGAKEAVK
AGRGRENTLK EEVEVLNKDL QKSLKTQSKL QGEKEERDEE IQELKQRIKR LNSGLQGQSE
HEGKGPTVEA LQKKIRKLES ELERRGVPES TTERKGLGLK DDKTNKEEIV RWEEGKKWQA
RMEKVRNILK EKERETESVS KQLSTLKELY ARLEQEKAGL QRKLKGRGVT ADQVVGVRTQ
ESEKELVELK RRNAELEQQI LTIKQQQALP RDSAMEDMNL RNHYLEDRLH SLESQKSSEG
RSLVSPSVSL KELRSLTFDV GDVHEKKRVL TFLANDSVAY QRDGTSAHKE GALHPNQGQK
ETQTVFDGTN DCVPETERTE KPSRAERGEQ ERTDETGEGG HEEQTEDIGE GEQGETEETD
RESKQENREK SDAESENVNE VAVAELVDIT TEENLIARQD STSDTVLDLS VPKP
//
