ID A0A1S3KTH4_SALSA Unreviewed; 337 AA.
AC A0A1S3KTH4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cathepsin L1-like {ECO:0000313|RefSeq:XP_013981900.1};
GN Name=LOC106561951 {ECO:0000313|RefSeq:XP_013981900.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013981900.1};
RN [1] {ECO:0000313|RefSeq:XP_013981900.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013981900.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_013981900.1; XM_014126425.1.
DR AlphaFoldDB; A0A1S3KTH4; -.
DR GeneID; 106561951; -.
DR KEGG; sasa:106561951; -.
DR OrthoDB; 5490122at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..337
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018618878"
FT DOMAIN 30..89
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 117..336
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 337 AA; 38102 MW; 97165C1426018FE7 CRC64;
MMSLYLAVLV LCMSAVYAAP MFDSQLEGHW HLWKNWHSKN YHESEQGWRR MVWEKNLKKI
EMHNLDHTMG KHSYRLGMNH FGDMTNEEFG QLMNGYKQTT ERKYKGSLFM EPSYLQAPEA
VDWREKGYVT PVMDQGSCGS CWAFSSTGAI EGQLFRKTGN LVSLSEQNLV DCSRPQGNEG
CNGGLMDLAF QYVKDNGGLD TEASYPYVGK DDLCHYRPEF SAVNETGFVD IPSGKEHALM
SAVASVGPVS VAIDGSHESF QFYQSGIYYE EECSSEQLDH GVLVVGYSFE GEDVDGKKFW
IVKNSWSEKW GDKGYIYMAK DRKNHCGIAT AASYPLV
//
