ID A0A1S3KTJ4_SALSA Unreviewed; 1895 AA.
AC A0A1S3KTJ4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 5-like {ECO:0000313|RefSeq:XP_013982013.1};
GN Name=LOC106562014 {ECO:0000313|RefSeq:XP_013982013.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013982013.1};
RN [1] {ECO:0000313|RefSeq:XP_013982013.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR RefSeq; XP_013982013.1; XM_014126538.1.
DR STRING; 8030.ENSSSAP00000078650; -.
DR KEGG; sasa:106562014; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 17.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 14.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SMART; SM00261; FU; 22.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 7.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010324487"
FT TRANSMEM 1770..1791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 480..620
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 193..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1796..1833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 188
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 229
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 405
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1895 AA; 207342 MW; 13CE6699A2E2A334 CRC64;
MTRNVPLSTG MVVLSAFLWM GSLVPLCQPL IYTNDWAVRI NGAPASADSI AEKYGFHNLG
QIGDLNNFYS FRHSGTVERS TLSNKDFTDL IAKETKVEWV QQQVVHWRTK RNSRASHIYS
IDVRTKHIHP GPVQPNQTQT LVFNDPQWCS LWYIHCSEGS QGCPSYMNIE GAWRRGHTGK
GVVVSVLDDG IEREHPDLRP NYDPFASYDF NGNDDDPTPR YDSSNDNSHG TKCAGMVAAA
ANNSQCTVGI SFNARIGGIR MLDGDVTDIV EAQSLSFRQQ HIDIYSASWG PEDDGRTVEG
PGPLARLALD NGIRTGRKGR GSIFVWASGN GGRSRDHCSC DGYTNSIYTI SISSTTHSGA
RPDYLEPCPS TLASTYSSFS TDRQGAKMVT LDLKQGCSKE HSGTSVSAPM AAGVIALALE
ANPLLTWRDV QHIIVRTSQA SHLTSPDWHT NGAGYQVSHL YGFGLLDAES MVKEAERWRL
VPSQHVCKEA PTQQSRTIPP GLVLRSVYES TGCSLHPLQH IVYLEHVVIH VTITHSHRGD
LSITLTSPTG TKSQLLANRP LDHSTEGFQS WEFMTTHCWG EKASGDWSLE VLDTPSQQRD
NSETGELREW SLVLYGTSEQ PYSMRREQAR SAELPTDGGD LTEEYNGRCD PECSEDGCEG
PGPQQCVTCL HLFLKFKNNT RTCVSVCPVG FWGDRRRCKK CFSSCEICTG SRSDQCTTCR
AGHHLTEGTS SCTASCGDNY YLDHDANMCR KCSENCLRCT SANICTECKS GTSLLGNRCQ
RSCGPGSYHN EQESTCEPCH EACATCAGAG IESCNQCADG YLMEEWRCVS SCSVGFYATE
SSPQKTSDGP RICRRCDSSC LTCVGAGKGN CSSCAGGHSL MDKMCMVSTV CGDGEYQDSH
GKCHACDATC LKCTGPKSEE CISCGPSRSL DQGCCVAQCA RGKYQSGGQC HLCDHTCAMC
LDGGPANCTS CDTDKFNMDR YLYKGGCVDA CPEGHYHTQE KSCEACPDNC KLCSSATHCL
RCNSSYYTTD GVCTRLECGE GEVEDPEYDD CMACEEGCKK CVLYNPRHCL SCTDGFYKFQ
DGCYKNCPAK TFSVEEEMTC VPCDEKCVSC DEHECYWCET DLFLSEGKCV PECPDGFYGD
EDTQECEECH SDCVTCSGPD SDDCVLCEEG TSREEGECVS KQDSCPVKTF LTGEGECEAC
HASCDSCSGE EKSQCKTCVK GRFLSAEQVC VLKCPASSFA SRLSGVCEPC PRGCAQCVDE
HRCTRCQVVR KAPLYLQDGQ CVRQCQSGYA AGQVCRGCAT GCASCEKNAT HCLSCVEPFL
LYKHHCVEAC PPAHTLRDGE CQHCPTACQE CSPNSECTGC EEYHFLYEGR CVMDCPERFF
RDSEQDVCVR CHPDCARCDG PDGDDCDSCA DPEATLHNGA CLPNCPSHTY RDSRTGQCKD
CDGSCLTCSG PHAGSCSSCR EGQKLDAEGQ CDPLVNRCTP RHYTDQDGEC HPCHKYCQQC
NGPGKSHCLS CNQNHFILNG TCMDFCPTGF YQEESSQRCE GCHPACLTCM GRHSHECLSC
KDHLFREGKE CVDTCQPSHY GNMTSRTCER CDPSCGECSG GRADGCLNCA DGLLYLRKQG
RCHSSCPQGH YQDSQHHTCE PCHSSCRTCS GKGSQACDLC HMGYTLSDGM CESHCNMGQY
PVLQDCEDCD GSCLDCSGPG PYNCTICPAH AILTAGGRCL LCCQNDLPVE GDSTAQQQQE
CCNCTETRGE CVLSTNLAFR NDEEESTGNM ALFITTSILL LLGLGTIVFL IRRSRSKSPS
LPDPITAPRG YEKLGGGRHN TTSAGHASSS GHFREAQLVD LTDRYGDKDE EDEDEDEDIV
YMGQDGTVYR KFRYGQPGND NDDELEYDDE SYTFR
//
