ID   A0A1S3KXJ2_SALSA        Unreviewed;       803 AA.
AC   A0A1S3KXJ2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like isoform X5 {ECO:0000313|RefSeq:XP_013983330.1};
GN   Name=LOC106562829 {ECO:0000313|RefSeq:XP_013983330.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013983330.1};
RN   [1] {ECO:0000313|RefSeq:XP_013983330.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013983330.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013983330.1; XM_014127855.1.
DR   AlphaFoldDB; A0A1S3KXJ2; -.
DR   GeneID; 106562829; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa11.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17209; RA_RalGDS; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR015758; RalGDS_RA.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          68..198
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          235..500
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          687..774
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          515..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   803 AA;  89959 MW;  39944A83BE551FBB CRC64;
     MMMLDTQNAT QEIGEEVEDG VVYTITLRKV QMLHHHHHPG HHIGGSGAIK GQRWLGVDAS
     LSLYETCKVR TIKAGTLEKL VEYMVAAFRG NDSTYVTIFL CTYRSFASTK QVLDLLLNRY
     AKLQHLPGSE GHRLTHDDRT DLRNTISSIL GAWLDQYSED FWNPPEYSCL RRLISYLHLN
     FPGSDLERRA CNLLAHFDRR QLQEPESESL DHGGYPFTLL ENGYEDDRLD FLNFDPAVVA
     EQFTLMDAEL FKKVVPYHCL GSIWSQRDKK GKEHLAPTIR ATVTQFNCVT NCVIATCLSE
     RLLKPTQRAK LVERWIEVAR ECRILKNFSS LRAILSALQC NPVHRLKRTW DEVSRENFRI
     FHELSEIFSD ENNHSLSREL LIKEGTSKFA TLEINPKRAQ KRQQQPRDLS VMQGTIPYLG
     TFLTDLVMMD TAMKDYLDGG LIHFEKRRKE FEVIAQIKLL QLACNNYNFT RNKRFRQWFS
     GVDKLTEAES YSQSCEIEPL SESASNTLKK KNTGIIKRWS DRQPASSEPG YCSAGSSHSK
     SFDQLRYAPC LGGSSGGGGG DGADSLSVTS AGSSSSDVEE INISFISDSP DAHERKTSTP
     SVKHSNSTLG KCGPLPDLAP TFWESTSLSS LDASGVGSGS GSSSASSSSM SSTPVVGAGS
     RSHKRSVSGV SNYSSLSLPL YNQQVDDCCI IRVSLDVDNG NMYKSILVTS QDKTPAVIRK
     AMVKHNLDRE RAEDYELLQK ISEEKELKIP DNANVFYAMN SSANYDFVLK KHGFPKVCRT
     KHVASSTLPR MKQKGLKIGK GIF
//