ID   A0A1S3KXS9_SALSA        Unreviewed;      1192 AA.
AC   A0A1S3KXS9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Rap guanine nucleotide exchange factor 1-like isoform X6 {ECO:0000313|RefSeq:XP_013983395.1};
GN   Name=LOC106562868 {ECO:0000313|RefSeq:XP_013983395.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013983395.1};
RN   [1] {ECO:0000313|RefSeq:XP_013983395.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013983395.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013983395.1; XM_014127920.1.
DR   AlphaFoldDB; A0A1S3KXS9; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa11.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          803..925
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          955..1179
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..447
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        759..779
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1192 AA;  133982 MW;  3BF1ABD235A67AD2 CRC64;
     MGNTSWRSQG SSEDADSLHG ELDEEQSDSQ RSHLSSFTMK LKDRFHSPKI KRTPSKKGKQ
     LQVEPAVKSQ EKPVNKKVSR LEEQEKEVVS ALRYFKTIVD KIMVEKKVLE MLPGSASKVL
     EAILPLVQVE ARITHSSAVS SCHNRVYQSL ANLIRWSDQV MLDDIDLDDK DNVVAVTTVI
     KAVLDGVKEL VKLTIEKQEQ PSPTTLNKPP PPIATPESTS ELPLTERERE ILSKTTPTVP
     PTEDMTDMAE EDIAPPKPPL PGLKMDALRA HLATDHFVAA QRRSTKTDTP PPALPPKKRQ
     SAPSPTRVAV VTPMSRGSSL PCSVHRRQQD YEQEFLQRRF SGGSQSYRGN SPRLSPCSSM
     GKLSKSDEHL CSMEQDSGQC SQNTSCETLD NTESYDPDYD FLHQDLSVFT GDPLAPSGVT
     SLSPLPESHS ESSSPSPVPP PTRFSSPPAP HSEYWTPQPG SHISPLHPCR LSAPPALPQK
     KRRSTQVSPY PDGCWGGSSR GPLYERFPSQ YDNLSEEELL HPTPPFPLFT PISPMPQSNG
     GVFVAQYLAS ENADIPSSPP PLPEKRNKHV LAYMQFVEDY SEPQPSVFYQ TPQSESIYEQ
     RNKRFQEVYG FNDSFSSTDS VHDPLPIPLF PPPALPPKQR QLVSLPTLHQ SKSSDQVALA
     DATLLAGSGD GPNGSLADRL GSVAVCLPSS ETTSLLTDSL LHTSAVSVDE GGEGEYVNLY
     SSSQANGELE LPLCLREPNS ADDVLQDPSP QMPSSNSKEA LDKDSRRQKS TDSAPCDEEV
     DELSLIDHKE IMSRITLKQE NDDGPDVRAG SGDILLVHAT ETERKDLVLY CEAFLTTYRT
     FISPEDLIKK LHYRYTRFCH SPDTFKKRVS KNTFFVLVRV VDELCLVELT EDILKQLMDL
     VFRLVCNGEL SLARVLRKNI LDKVEQKKLL RCTNSLKPLA ARGVSARPGT LHDFRSHEIA
     DQLTLLDAEL FYKIEIPEVL LWAKEQNEEK SPNLTQFTEH FNNMSYWVRS LIIQQEKAQD
     REKLLLKFIK IMKHLRKLNN FNSYLAILSA LDSAPIRRLE WQKQTSEGLE EYCTLIDSSS
     SFRAYRAALA DVEPPCIPYL GLILQDLTFV HLGNPDLIDG KVNFSKRWQQ FNILDSMRRF
     QQVHYELKRN DDIVCFFNDF SDHLAEEALW ELSLKIKPRN ITRRRTEREE KT
//