ID A0A1S3KYM4_SALSA Unreviewed; 624 AA.
AC A0A1S3KYM4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X2 {ECO:0000313|RefSeq:XP_013983680.1};
GN Name=LOC106563018 {ECO:0000313|RefSeq:XP_013983680.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013983680.1};
RN [1] {ECO:0000313|RefSeq:XP_013983680.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013983680.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR RefSeq; XP_013983680.1; XM_014128205.1.
DR AlphaFoldDB; A0A1S3KYM4; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000087266; Chromosome ssa11.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 11..197
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 231..326
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 524..618
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 340..374
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 426..460
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 624 AA; 71956 MW; A5AD966995636D16 CRC64;
MLGKAVGSAL LDLTEQFSLP ETAPPMLARL LEAIEKKGLD NPTLYRTFTA GGGLDVRQCF
DTDPPSADLD QMDLQMLCDG LSRYLQDLPQ PVILPAIYTQ LVHTAQEVQS PEECAQQLRH
IASAPSLPAQ YWLTFHCLLR HWSRVCHNAP KNLLSSRVLG EIFSPLLFRQ QAASCEPSPD
AHIKIIETLV TSEWTEAQAA PALPPKPPKP TAPAVTNNGM NNNMALQDGE WYWGDISREE
VNEKLRDTAD GTFLVRDAST KMHGDYTLTL RKGGNNKLIK IFHRDGKYGF SDPLTFNSVV
ELINHYRNES LAQYNPKLDV KLQFPVSKHQ QDQVVKEDNI EAVGKKLHEY HQQYQEKNRE
YDRLYEEYTR TSQEIQMKRT AIEAFNETIK IFEEQCQTQE RYSKEYIEKF RREGNDKEIQ
RIMGNYEKLK SRISEIVDSK RRLEEDLKKQ AADYREIDKR MNSIKPDLIQ LRKTRDQYLM
WLTQKGVRQK KLNEWLEIKN ENTEDQYSMV DDDEDLPHHD ERSWKLGNIN RLQAEALLRG
KRDGTFLVRD SSKAGCYACS VVVEGEVKHC VINKTPSGFG FAEPYNLYNS LKELVLHYQH
TSLVQHNDSL NVTLAHPVYA QQKR
//
