ID A0A1S3L106_SALSA Unreviewed; 1264 AA.
AC A0A1S3L106;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 3-like isoform X2 {ECO:0000313|RefSeq:XP_013984505.1};
GN Name=LOC106563447 {ECO:0000313|RefSeq:XP_013984505.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013984505.1};
RN [1] {ECO:0000313|RefSeq:XP_013984505.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013984505.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_013984505.1; XM_014129030.1.
DR AlphaFoldDB; A0A1S3L106; -.
DR GeneID; 106563447; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000087266; Chromosome ssa11.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 10.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 14.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 12.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1264
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010335519"
FT DOMAIN 79..111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..261
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 342..394
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 523..566
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 567..609
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 650..690
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..731
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 732..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 772..814
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 824..878
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 943..979
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1036..1076
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1086..1139
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1207..1248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 193..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 83..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 101..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1264 AA; 139674 MW; 190BE097CC03A89F CRC64;
MPSLIISHLL VIWLGVQRLA WCAERASTRE RFKVVIAPLI CKRMCLKGQC QDTCEQGNNT
TLIGENGQSA DTLTGPGFRV VVCPLTCMNG GVCSSRTHCL CPPGFTGRLC QFPLRQMPEA
QAARGNKQPV YTLSVLPDGQ SQGEQVAMGR PQLTQTHSVF TLPLAQGAGH HSSEVQFNVR
VHHTHDTSVI IRPLDQSNSK PPHKTVTRLT PQTHKPRGRC FQETTPKQAC SSTPLPVLTN
QEDCCGSVGN SWGQNKCYKC PKLPYAGVKL QTIIEDYGST CPLGYKRLNS THCQDINECT
MQGVCQNGDC LNTQGSFLCA CKPGFTLDRT RCVESPSPVE QAQCFLMATD VGRCEHALPT
HLSQEMCCCT VGKAWGSSCE RCPQDGTASF SKICPAGKGY FLHSVRETVA FPPQIHTSLK
QEHKQEEVKP PEEPPETTTP MQLSTHAPRG PEIITKPTPP PIIRLNPDSD PLEVAQTQVS
QTDECRLNRN LCGHGECVNV HTGYKCECYA GYRLHPQRNA CVDDDECDAE PCGHGRGICI
NTEGSYRCRC LHGYKLLVYH GKVRCVDVNE CSKPDICGQG GQCVNLPGSY KCDCHKGFRS
KSQRQPACED INECLDPSSC PNEQCENTPG SYECVPCFSG HQAQGGVCYD VNECQKRGVC
PNGRCENLPG TYRCLCNEGF LSAADSKGCR DIDECEDERL CANGRCVNTE GSFQCQCYPG
YQRTQEGSHC EDINECERPS NCQRGRCINS MGSYRCECQK GYMLVGGRRC QDIDECATDR
GLCQPHGVCE NRQGSYVCVC KDGFILSEDK HSCEEIEVDM EDKKECYLNL DDTVFCDSVL
ATNVTKQECC CSIGVGWGDH CEIYPCPVYH SSEFHSLCPV GRGFYQEEGV TGYGLSVHID
IDECVLFSNE ICKEGRCMNT QPGYECYCQQ GFYYDSNLLE CIDVNECHDE SLCTNGQCKN
TRGSFYCTCN SPWTPDASSK KCVIPTVAGV DECQDPLNCK SGHCVDTPGS YYCICSPPWI
LATDRNSCVT LEEQADINEC QDPSYCKNGR CVNTPGSFHC ICTQPLTFSA ALKQCVYDDR
TAAHKDVCFL QVDEDLICSH PRNGLVFTYS ECCCHYGRGW GPECRTCPQR NSVIFNRLCD
MHLETESDGE GDFLAAFANY NPEGDSSEED SDECSCANGR CVRSYLSTMC DCNTGFRLDH
SRTRCTDIDE CAEPGVRVNP CKNARCVNSI GSFKCYCKNG FVPARRPNMC VPGSKAQHIH
SRAL
//
