ID   A0A1S3L131_SALSA        Unreviewed;      1203 AA.
AC   A0A1S3L131;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Signal-induced proliferation-associated protein 1-like isoform X8 {ECO:0000313|RefSeq:XP_013984530.1};
GN   Name=LOC106563451 {ECO:0000313|RefSeq:XP_013984530.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013984530.1};
RN   [1] {ECO:0000313|RefSeq:XP_013984530.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013984530.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013984530.1; XM_014129055.1.
DR   AlphaFoldDB; A0A1S3L131; -.
DR   OrthoDB; 25782at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa11.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF14; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          473..690
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          79..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..1014
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1172..1203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        949..968
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        969..995
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1188..1203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1203 AA;  132689 MW;  812E747C6E97C5AD CRC64;
     MQSDDLFLRK FCRQRPRPPL TTVNFDSKRE GGVRARVVAG EWPPRRDGTD GESLTTPSCV
     GLNLRSVGRG HIMQRSNSDV TLGDLDSSGK AGGKATRAVG EKAGAGAQED SGVVLHREYG
     SLSSLERQIG LSGTQEPSAE DQGILSPNAL RFKDPFLLLG LQGTPPEPDG FFRALSTPAG
     DTPKPAKPPK PEGLSKKAKP SPPQIPQPGP YDNLGGGAWV RNFAHYDVQS ILFDLTEAAS
     NRDSIGRKKN ITSGASAAST MRPLTQATPS SPSQGGGGVG GTVEDPSLDE GDGNDNELLL
     SCPHFRNEMG GEERAGLGHT QGRGGLWLSL RNPNDAVSVL EEPRESHVQQ QGKSNYFIEH
     ADLGAHYYRK YFYMKDHQNF FGMDDRLGPV AISFRREEKE GSSGAQYNYR IIFRTTELKT
     LRGSILEESV PSAARHTTPR GLSPKRLLEF IIPELNLHCL RLASTSPKVR DTLLKLDEQG
     LNFQRKVGVM YCRAGQSSEE DMYNNESSGP AFEEFLDLLG ERVNLKGWEK YRAQLDTKTD
     STGTQSLYTH YQDYEVMFHV STMLPYTANN TQQLLRKRHI GNDIVTIVFQ EPGALPFTPK
     AIRSHFQHVF IIVQVEQSCS DHTYYRVAVT RSKDIPLFGP LFPKGARFPR SPAFRDFLLA
     KAVNAENAAE KAEKFRSMAT RTRQEYLKDL AENYVTTTPI DSSTKFPLLS LGSKRKDKLK
     GAKGAELHSA GALVWAVMAT SGNEGETGGH KLPCLLGVSA ESVVLIERYT RRVVFNCCCR
     DVIGWKAVID SRAIGGPCLD IFYERGEAVS ISVMDSQAEE IREMVQRLEL VTRGCEAREV
     TPLRDGVGQP GFLMSEEGFV TDLQRFGYAE SGGLQLGARV VRLCGHVLVH LGPEERTRLL
     RTAHKIHITV IPPDENGKPR RSFSELYQKA IQDAERKPGE GQSGEAWVLD EREEEEEEEM
     EEEEREQGEG KEAETMEGPA EGGEAEDRLS ETGLGEEDQG DQGDQGSLLS PPSLPLLRAT
     SLQDHPLNQT VEITPSQLTR SYSLERHPSC RDICDRHLYD NVGVKLKHHI YENPGELRDA
     TPDLILAVKP KMPLDEEQFV GAELGEERPS ASDPSLSSTR LSCLNRAERN SRALSLHNSI
     TKILSETTDS SEEEWQSIAD LATACRSILE ALSREAGDGT QGADSLTDGK LKDMKDRNKD
     ISK
//